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Table 2 P53, BCL-2 and Cyclin D1 expression in GISTs related to clinicopathological features

From: P53 expression is significantly correlated with high risk of malignancy and epithelioid differentiation in GISTs. An immunohistochemical study of 104 cases

  Tumor size (cm) Mitotic rate/50 HPF Malignancy risk F Malignancy risk M
  <2 2–5 5–10 >10 <5 5–10 >10 very
low
low intermediate high prob
benign
low prob
malign
P53 2/10 7/31 22/37 9/22 13/50 7/15 20/35 1/10 3/25 10/18 26/47 3/24 5/17 32/59
  20% 23% 37% 41% 26% 47% 57% 10% 12% 56% 55% 13% 29% 54%
BCL2 5/9 22/30 30/37 15/22 34/48 9/15 29/35 4/8 18/25 15/18 35/47 13/22 14/17 45/59
  56% 73% 81% 68% 71% 60% 83% 50% 72% 83% 74% 59% 82% 76%
CyD1 3/7 12/26 15/29 4/18 19/40 5/12 10/28 2/5 10/21 8/16 14/38 6/18 8/15 20/47
  43% 46% 52% 22% 48% 42% 36% 40% 47% 50% 37% 33% 53% 42%
  Nuclear atypia Proliferative
activity
Histological
subtype
Tumor site     
  absent mild severe <7% ≥ 7% spindle
cell
epithelioid stomach small
intestine
large
intestine
    
P53 6/26 13/37 21/37 14/60 22/40 18/63 22/37 19/58 16/35 5/7     
  23% 35% 56% 23% 55% 29% 59% 33% 46% 71%     
BCL2 18/25 25/36 29/37 9/26 27/72 43/61 29/37 37/56 30/35 5/7     
  72% 69% 78% 35% 38% 70% 78% 66% 86% 71%     
CyD1 9/18 9/28 16/34 21/46 12/34 21/48 13/32 17/45 15/30 2/5     
  50% 32% 47% 46% 35% 44% 41% 38% 50% 40%     
  1. CyD1: Cyclin D1, Figures 2/10 describe 2 out of 10 cases, bold: statistical significance, HPF: microscopic high power fields, F: Fletcher [10], M Miettinen [11], prob malign: probably malignant