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Table 3 The effect of the various patterns of breast cancer in the family on the age of onset of breast cancer in the women under study (multivariate)

From: A family history of breast cancer will not predict female early onset breast cancer in a population-based setting

Family characteristics

Relative risk at

age 30 *

95% C.I. of

relative risk at

age 30

Change of

relative risk per

10 years **

Overall

Significance

***

≥ 2 cases of female breast cancer in first or second-degree relatives (yes vs. no)

3.09

1.28–7.44

0.745

 

≥ 2 cases of female breast cancer under age 50 (yes vs. no)

3.36

1.12–10.08

0.489

 

≥ 1 case of female breast cancer under age 40 (yes vs. no)

2.06

0.83–5.12

1.000

 

Bilateral breast cancer in affected sister (index patient) (yes vs. no)

3.47

1.33–9.05

0.834

< .001

Model score ****

    

   0 *****

1

   

   1

2.01

(0.89–4.55)

0.942

 

   ≥ 2

10.62

(4.22–26.72)

0.430

<.001

  1. * Due to low prevalence, the hazard ratio can be considered as a relative risk.
  2. ** The relative risk at age 30 can be multiplied with this factor for calculating the relative risk at age 40, age 50 and so on.
  3. *** Model significance was based on the likelihood ratio of the final model as compared to the O-model without any covariate.
  4. **** Model score based on the family characteristics included in the multivariate model, each characteristic present yields one point.
  5. ***** Reference category.