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Table 3 The effect of the various patterns of breast cancer in the family on the age of onset of breast cancer in the women under study (multivariate)

From: A family history of breast cancer will not predict female early onset breast cancer in a population-based setting

Family characteristics Relative risk at
age 30 *
95% C.I. of
relative risk at
age 30
Change of
relative risk per
10 years **
Overall
Significance
***
≥ 2 cases of female breast cancer in first or second-degree relatives (yes vs. no) 3.09 1.28–7.44 0.745  
≥ 2 cases of female breast cancer under age 50 (yes vs. no) 3.36 1.12–10.08 0.489  
≥ 1 case of female breast cancer under age 40 (yes vs. no) 2.06 0.83–5.12 1.000  
Bilateral breast cancer in affected sister (index patient) (yes vs. no) 3.47 1.33–9.05 0.834 < .001
Model score ****     
   0 ***** 1    
   1 2.01 (0.89–4.55) 0.942  
   ≥ 2 10.62 (4.22–26.72) 0.430 <.001
  1. * Due to low prevalence, the hazard ratio can be considered as a relative risk.
  2. ** The relative risk at age 30 can be multiplied with this factor for calculating the relative risk at age 40, age 50 and so on.
  3. *** Model significance was based on the likelihood ratio of the final model as compared to the O-model without any covariate.
  4. **** Model score based on the family characteristics included in the multivariate model, each characteristic present yields one point.
  5. ***** Reference category.