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Table 1 Summary of the models required for fitting.

From: Cell killing and resistance in pre-operative breast cancer chemotherapy

Model type

Resistance

Sensitivity shift

Parameters

Cases

Level I

NO

NO

Sp, Sq (1)

17/35

Level II

YES

NO

Sp, Sq, IniR (2)

9/35

Level III

NO

YES

Sp, Sq, Sp2, Sq2 (3)

9/35

  1. (1) fraction of cycling (Sp) and quiescent (Sq) cells surviving a single cycle of therapy.
  2. (2) fraction of cells resistant to treatment (calculated at time zero)
  3. (3) fraction of cells surviving a single cycle of therapy in the first (Sp, Sq) and second (Sp2, Sq2) phase sensitivity.