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Figure 2 | BMC Cancer

Figure 2

From: Cell killing and resistance in pre-operative breast cancer chemotherapy

Figure 2

Examples of fitting. Representative examples of fitting (continuous magenta line) of experimental time courses (dots). The arrows indicate treatment times. Outlines of cycling (green line) and quiescent (light blue line) cells predicted by the model are also reported. Panel A: fitting with a level I model, with Sp = 0.68 and Sq = 0.98 (k = 0.50). Panel B: fitting with a level II model, including a subpopulation of cells resistant to treatment (dashed line). The fit was obtained with Sp = 0.04, Sq = 0.90 and IniR = 0.01 (k = 0.83). Panel C: fitting with a level III model, with an increase of efficacy from the fourth cycle. The fit was obtained with Sp = 0.43 and Sq = 0.98 up to day 60 and Sp = 0.004 and Sq = 0.98 thereafter (k = 0.50). Panel D: an example of unsatisfactory fit, with Sp = 0.34 and Sq = 0.98 (k = 0.50).

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