Serum levels of Candidate Biomarkers in cirrhotic patients with and without HCC. Box plots comparing levels of AFP, PIVKAII, GP3, SCCA-1 and Follistatin are shown. Levels are presented as ng/ml, except for AFP where the log data are presented in order to accommodate the wide range. The mean between the two groups is significantly different for both AFP and PIVKAII. For the latter, this is predominantly a result of a marked increase in levels in individuals with tumours greater than 5 cm in size.