TY - JOUR AU - Jain, R. K. PY - 1987 DA - 1987// TI - Transport of molecules in the tumor interstitium: a review JO - Cancer Res VL - 47 ID - Jain1987 ER - TY - JOUR AU - Jain, R. K. PY - 1987 DA - 1987// TI - Transport of molecules across tumor vasculature JO - Cancer Metastasis Rev VL - 6 UR - https://doi.org/10.1007/BF00047468 DO - 10.1007/BF00047468 ID - Jain1987 ER - TY - JOUR AU - Heldin, C. H. AU - Rubin, K. AU - Pietras, K. AU - Ostman, A. PY - 2004 DA - 2004// TI - High interstitial fluid pressure - an obstacle in cancer therapy JO - Nat Rev Cancer VL - 4 UR - https://doi.org/10.1038/nrc1456 DO - 10.1038/nrc1456 ID - Heldin2004 ER - TY - JOUR AU - Baluk, P. AU - Morikawa, S. AU - Haskell, A. AU - Mancuso, M. AU - McDonald, D. M. PY - 2003 DA - 2003// TI - Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors JO - Am J Pathol VL - 163 UR - https://doi.org/10.1016/S0002-9440(10)63540-7 DO - 10.1016/S0002-9440(10)63540-7 ID - Baluk2003 ER - TY - JOUR AU - Baxter, L. T. AU - Jain, R. K. PY - 1989 DA - 1989// TI - Transport of fluid and macromolecules in tumors I. Role of interstitial pressure and convection JO - Microvasc Res VL - 37 UR - https://doi.org/10.1016/0026-2862(89)90074-5 DO - 10.1016/0026-2862(89)90074-5 ID - Baxter1989 ER - TY - JOUR AU - Milosevic, M. AU - Fyles, A. AU - Hedley, D. AU - Hill, R. PY - 2004 DA - 2004// TI - The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure JO - Semin Radiat Oncol VL - 14 UR - https://doi.org/10.1016/j.semradonc.2004.04.006 DO - 10.1016/j.semradonc.2004.04.006 ID - Milosevic2004 ER - TY - JOUR AU - Milosevic, M. AU - Fyles, A. AU - Hedley, D. AU - Pintilie, M. AU - Levin, W. AU - Manchul, L. AU - Hill, R. PY - 2001 DA - 2001// TI - Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements JO - Cancer Res VL - 61 ID - Milosevic2001 ER - TY - JOUR AU - Jain, R. K. PY - 2005 DA - 2005// TI - Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy JO - Science VL - 307 UR - https://doi.org/10.1126/science.1104819 DO - 10.1126/science.1104819 ID - Jain2005 ER - TY - JOUR AU - Fyles, A. AU - Milosevic, M. AU - Pintilie, M. AU - Syed, A. AU - Levin, W. AU - Manchul, L. AU - Hill, R. P. PY - 2006 DA - 2006// TI - Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer JO - Radiother Oncol VL - 80 UR - https://doi.org/10.1016/j.radonc.2006.07.014 DO - 10.1016/j.radonc.2006.07.014 ID - Fyles2006 ER - TY - JOUR AU - Eikenes, L. AU - Bruland, O. S. AU - Brekken, C. AU - Davies Cde, L. PY - 2004 DA - 2004// TI - Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-03-1472 DO - 10.1158/0008-5472.CAN-03-1472 ID - Eikenes2004 ER - TY - JOUR AU - Pietras, K. AU - Ostman, A. AU - Sjoquist, M. AU - Buchdunger, E. AU - Reed, R. K. AU - Heldin, C. H. AU - Rubin, K. PY - 2001 DA - 2001// TI - Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors JO - Cancer Res VL - 61 ID - Pietras2001 ER - TY - JOUR AU - Pietras, K. AU - Stumm, M. AU - Hubert, M. AU - Buchdunger, E. AU - Rubin, K. AU - Heldin, C. H. AU - McSheehy, P. AU - Wartmann, M. AU - Ostman, A. PY - 2003 DA - 2003// TI - STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake JO - Clin Cancer Res VL - 9 ID - Pietras2003 ER - TY - JOUR AU - Pietras, K. AU - Rubin, K. AU - Sjoblom, T. AU - Buchdunger, E. AU - Sjoquist, M. AU - Heldin, C. H. AU - Ostman, A. PY - 2002 DA - 2002// TI - Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy JO - Cancer Res VL - 62 ID - Pietras2002 ER - TY - JOUR AU - Rubin, K. AU - Sjoquist, M. AU - Gustafsson, A. M. AU - Isaksson, B. AU - Salvessen, G. AU - Reed, R. K. PY - 2000 DA - 2000// TI - Lowering of tumoral interstitial fluid pressure by prostaglandin E(1) is paralleled by an increased uptake of (51)Cr-EDTA JO - Int J Cancer VL - 86 UR - https://doi.org/3.0.CO;2-R DO - 3.0.CO;2-R ID - Rubin2000 ER - TY - JOUR AU - Salnikov, A. V. AU - Iversen, V. V. AU - Koisti, M. AU - Sundberg, C. AU - Johansson, L. AU - Stuhr, L. B. AU - Sjoquist, M. AU - Ahlstrom, H. AU - Reed, R. K. AU - Rubin, K. PY - 2003 DA - 2003// TI - Lowering of tumor interstitial fluid pressure specifically augments efficacy of chemotherapy JO - Faseb J VL - 17 ID - Salnikov2003 ER - TY - JOUR AU - Netti, P. A. AU - Baxter, L. T. AU - Boucher, Y. AU - Skalak, R. AU - Jain, R. K. PY - 1995 DA - 1995// TI - Time-dependent behaviour of interstitial fluid pressure in solid tumors: implications for drug delivery JO - Cancer Res VL - 55 ID - Netti1995 ER - TY - JOUR AU - Netti, P. A. AU - Hamberg, L. M. AU - Babich, J. W. AU - Kierstead, D. AU - Graham, W. AU - Hunter, G. J. AU - Wolf, G. L. AU - Fischman, A. AU - Boucher, Y. AU - Jain, R. K. PY - 1999 DA - 1999// TI - Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules JO - Proc Natl Acad Sci U S A VL - 96 UR - https://doi.org/10.1073/pnas.96.6.3137 DO - 10.1073/pnas.96.6.3137 ID - Netti1999 ER - TY - JOUR AU - Roh, H. D. AU - Kalnicki, S. AU - Buchsbaum, R. AU - Bloomer, W. D. AU - Jain, R. K. PY - 1991 DA - 1991// TI - Interstitial hypertension in carcinoma of uterine cervix in patients: Possible correlation with tumor oxygenation and radiation response. JO - Cancer Res VL - 51 ID - Roh1991 ER - TY - JOUR AU - Curti, B. D. AU - Urba, W. J. AU - Alvord, W. G. AU - Janik, J. E. AU - Smith, J. W. AU - Madara, K. AU - Longo, D. L. PY - 1993 DA - 1993// TI - Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment JO - Cancer Res VL - 53 ID - Curti1993 ER - TY - JOUR AU - Rofstad, E. K. AU - Tunheim, S. H. AU - Mathiesen, B. AU - Graff, B. A. AU - Halsor, E. F. AU - Nilsen, K. AU - Galappathi, K. PY - 2002 DA - 2002// TI - Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts JO - Cancer Res VL - 62 ID - Rofstad2002 ER - TY - JOUR AU - Less, J. R. AU - Posner, M. C. AU - Boucher, Y. AU - Borochovitz, D. AU - Wolmark, N. AU - Jain, R. K. PY - 1992 DA - 1992// TI - Interstitial hypertension in human breast and colorectal tumors JO - Cancer Res VL - 52 ID - Less1992 ER - TY - JOUR AU - Taghian, A. G. AU - Abi-Raad, R. AU - Assaad, S. I. AU - Casty, A. AU - Ancukiewicz, M. AU - Yeh, E. AU - Molokhia, P. AU - Attia, K. AU - Sullivan, T. AU - Kuter, I. AU - Boucher, Y. AU - Powell, S. N. PY - 2005 DA - 2005// TI - Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications JO - J Clin Oncol VL - 23 UR - https://doi.org/10.1200/JCO.2005.08.119 DO - 10.1200/JCO.2005.08.119 ID - Taghian2005 ER - TY - JOUR AU - Nathanson, S. D. AU - Nelson, L. PY - 1994 DA - 1994// TI - Interstitial fluid pressure in breast cancer, benign breast conditions, and breast parenchyma JO - Ann Surg Oncol VL - 1 UR - https://doi.org/10.1007/BF03187139 DO - 10.1007/BF03187139 ID - Nathanson1994 ER - TY - JOUR AU - Boucher, Y. AU - Kirkwood, J. M. AU - Opacic, D. PY - 1991 DA - 1991// TI - Interstitial hypertension in superficial metastatic melanomas in humans JO - Cancer Res VL - 51 ID - Boucher1991 ER - TY - JOUR AU - DiResta, G. R. AU - Lee, J. AU - Larson, S. M. AU - Arbit, E. PY - 1993 DA - 1993// TI - Characterization of neuroblastoma xenograft in rat flank. I. Growth, interstitial fluid pressure, and interstitial fluid velocity distribution profiles JO - Microvasc Res VL - 46 UR - https://doi.org/10.1006/mvre.1993.1044 DO - 10.1006/mvre.1993.1044 ID - DiResta1993 ER - TY - JOUR AU - Boucher, Y. AU - Lee, I. AU - Jain, R. K. PY - 1995 DA - 1995// TI - Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors JO - Microvasc Res VL - 50 UR - https://doi.org/10.1006/mvre.1995.1051 DO - 10.1006/mvre.1995.1051 ID - Boucher1995 ER - TY - JOUR AU - Hori, K. AU - Suzuki, M. AU - Saito, S. AU - Tanda, S. AU - Zhang, Q. H. AU - Li, H. C. PY - 1994 DA - 1994// TI - Changes in vessel pressure and interstitial fluid pressure of normal subcutis and subcutaneous tumor in rats due to angiotensin II JO - Microvasc Res VL - 48 UR - https://doi.org/10.1006/mvre.1994.1052 DO - 10.1006/mvre.1994.1052 ID - Hori1994 ER - TY - JOUR AU - Znati, C. A. AU - Rosenstein, M. AU - Boucher, Y. AU - Epperly, M. W. AU - Bloomer, W. D. AU - Jain, R. K. PY - 1996 DA - 1996// TI - Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft JO - Cancer Res VL - 56 ID - Znati1996 ER - TY - JOUR AU - Kerbel, R. S. AU - Cornil, I. AU - Theodorescu, D. PY - 1991 DA - 1991// TI - Importance of orthotopic transplantation procedures in assessing the effects of transfected genes on human tumor growth and metastasis JO - Cancer Metastasis Rev VL - 10 UR - https://doi.org/10.1007/BF00050792 DO - 10.1007/BF00050792 ID - Kerbel1991 ER - TY - JOUR AU - Brekken, C. AU - Bruland, O. S. AU - de Lange Davies, C. PY - 2000 DA - 2000// TI - Interstitial fluid pressure in human osteosarcoma xenografts: significance of implantation site and the response to intratumoral injection of hyaluronidase JO - Anticancer Res VL - 20 ID - Brekken2000 ER - TY - JOUR AU - Cairns, R. A. AU - Hill, R. P. PY - 2004 DA - 2004// TI - Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-03-3196 DO - 10.1158/0008-5472.CAN-03-3196 ID - Cairns2004 ER - TY - JOUR AU - Cairns, R. A. AU - Kalliomaki, T. AU - Hill, R. P. PY - 2001 DA - 2001// TI - Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors JO - Cancer Res VL - 61 ID - Cairns2001 ER - TY - JOUR AU - Guy, C. T. AU - Cardiff, R. D. AU - Muller, W. J. PY - 1992 DA - 1992// TI - Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease JO - Mol Cell Biol VL - 12 UR - https://doi.org/10.1128/MCB.12.3.954 DO - 10.1128/MCB.12.3.954 ID - Guy1992 ER - TY - JOUR AU - Hagendoorn, J. AU - Tong, R. AU - Fukumura, D. AU - Lin, Q. AU - Lobo, J. AU - Padera, T. P. AU - Xu, L. AU - Kucherlapati, R. AU - Jain, R. K. PY - 2006 DA - 2006// TI - Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-2655 DO - 10.1158/0008-5472.CAN-05-2655 ID - Hagendoorn2006 ER - TY - JOUR AU - Bristow, R. G. AU - Hardy, P. A. AU - Hill, R. P. PY - 1990 DA - 1990// TI - Comparison between in vitro radiosensitivity and in vivo radioresponse of murine tumor cell lines. I: Parameters of in vitro radiosensitivity and endogenous cellular glutathione levels JO - Int J Radiat Oncol Biol Phys VL - 18 UR - https://doi.org/10.1016/0360-3016(90)90277-Q DO - 10.1016/0360-3016(90)90277-Q ID - Bristow1990 ER - TY - JOUR AU - Cairns, R. A. AU - Hill, R. P. PY - 2004 DA - 2004// TI - A fluorescent orthotopic model of metastatic cervical carcinoma JO - Clin Exp Metastasis VL - 21 UR - https://doi.org/10.1023/B:CLIN.0000037729.75981.9e DO - 10.1023/B:CLIN.0000037729.75981.9e ID - Cairns2004 ER - TY - JOUR AU - Young, S. D. AU - Marshall, R. S. AU - Hill, R. P. PY - 1988 DA - 1988// TI - Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells JO - Proc Natl Acad Sci U S A VL - 85 UR - https://doi.org/10.1073/pnas.85.24.9533 DO - 10.1073/pnas.85.24.9533 ID - Young1988 ER - TY - JOUR AU - Fadnes, H. O. AU - Reed, R. K. AU - Aukland, K. PY - 1977 DA - 1977// TI - Interstitial fluid pressure in rats measured with a modified wick technique JO - Microvasc Res VL - 14 UR - https://doi.org/10.1016/0026-2862(77)90138-8 DO - 10.1016/0026-2862(77)90138-8 ID - Fadnes1977 ER - TY - JOUR AU - Skliarenko, J. V. AU - Lunt, S. J. AU - Gordon, M. L. AU - Vitkin, A. AU - Milosevic, M. AU - Hill, R. P. PY - 2006 DA - 2006// TI - Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumors JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-2046 DO - 10.1158/0008-5472.CAN-05-2046 ID - Skliarenko2006 ER - TY - JOUR AU - Franco, M. AU - Man, S. AU - Chen, L. AU - Emmenegger, U. AU - Shaked, Y. AU - Cheung, A. M. AU - Brown, A. S. AU - Hicklin, D. J. AU - Foster, F. S. AU - Kerbel, R. S. PY - 2006 DA - 2006// TI - Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-3295 DO - 10.1158/0008-5472.CAN-05-3295 ID - Franco2006 ER - TY - JOUR AU - Yang, V. X. D. AU - Needles, A. AU - Vray, D. PY - 2004 DA - 2004// TI - High frequency ultrasound speckle flow imaging: comparison with doppler optical coherence tomography (DOCT). JO - Proc IEEE Ultrasound Symp VL - 1 ID - Yang2004 ER - TY - JOUR AU - Gutmann, R. AU - Leunig, M. AU - Feyh, J. AU - Goetz, A. E. AU - Messmer, K. AU - Kastenbauer, E. AU - Jain, R. K. PY - 1992 DA - 1992// TI - Interstitial hypertension in head and neck tumors in patients: correlation with tumor size JO - Cancer Res VL - 52 ID - Gutmann1992 ER - TY - JOUR AU - Podobnik, B. AU - Sersa, G. AU - Miklavcic, D. PY - 2001 DA - 2001// TI - Effect of hydralazine on interstitial fluid pressure in experimental tumours and in normal tissue JO - In Vivo VL - 15 ID - Podobnik2001 ER - TY - JOUR AU - Tufto, I. AU - Rofstad, E. K. PY - 1999 DA - 1999// TI - Interstitial fluid pressure and capillary diameter distribution in human melanoma xenografts JO - Microvasc Res VL - 58 UR - https://doi.org/10.1006/mvre.1999.2184 DO - 10.1006/mvre.1999.2184 ID - Tufto1999 ER - TY - JOUR AU - Tufto, I. AU - Rofstad, E. K. PY - 1995 DA - 1995// TI - Interstitial fluid pressure in human melanoma xenografts. Relationship to fractional tumor water content, tumor size, and tumor volume-doubling time JO - Acta Oncol VL - 34 UR - https://doi.org/10.3109/02841869509093990 DO - 10.3109/02841869509093990 ID - Tufto1995 ER - TY - JOUR AU - Rofstad, E. K. AU - Mathiesen, B. AU - Henriksen, K. AU - Kindem, K. AU - Galappathi, K. PY - 2005 DA - 2005// TI - The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-04-3039 DO - 10.1158/0008-5472.CAN-04-3039 ID - Rofstad2005 ER - TY - JOUR AU - De Jaeger, K. AU - Kavanagh, M. C. AU - Hill, R. P. PY - 2001 DA - 2001// TI - Relationship of hypoxia to metastatic ability in rodent tumours JO - Br J Cancer VL - 84 UR - https://doi.org/10.1054/bjoc.2001.1743 DO - 10.1054/bjoc.2001.1743 ID - De Jaeger2001 ER - TY - JOUR AU - Rofstad, E. K. AU - Danielsen, T. PY - 1999 DA - 1999// TI - Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis JO - Br J Cancer VL - 80 UR - https://doi.org/10.1038/sj.bjc.6690586 DO - 10.1038/sj.bjc.6690586 ID - Rofstad1999 ER - TY - JOUR AU - Rofstad, E. K. AU - Sundfor, K. AU - Lyng, H. AU - Trope, C. G. PY - 2000 DA - 2000// TI - Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis JO - Br J Cancer VL - 83 UR - https://doi.org/10.1054/bjoc.2000.1266 DO - 10.1054/bjoc.2000.1266 ID - Rofstad2000 ER - TY - JOUR AU - Rofstad, E. K. AU - Halsor, E. F. PY - 2002 DA - 2002// TI - Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8 JO - Br J Cancer VL - 86 UR - https://doi.org/10.1038/sj.bjc.6600052 DO - 10.1038/sj.bjc.6600052 ID - Rofstad2002 ER - TY - JOUR AU - Diresta, G. R. AU - Nathan, S. S. AU - Manoso, M. W. AU - Casas-Ganem, J. AU - Wyatt, C. AU - Kubo, T. AU - Boland, P. J. AU - Athanasian, E. A. AU - Miodownik, J. AU - Gorlick, R. AU - Healey, J. H. PY - 2005 DA - 2005// TI - Cell proliferation of cultured human cancer cells are affected by the elevated tumor pressures that exist in vivo JO - Ann Biomed Eng VL - 33 UR - https://doi.org/10.1007/s10439-005-5732-9 DO - 10.1007/s10439-005-5732-9 ID - Diresta2005 ER - TY - JOUR AU - Nathan, S. S. AU - DiResta, G. R. AU - Casas-Ganem, J. E. AU - Hoang, B. H. AU - Sowers, R. AU - Yang, R. AU - Huvos, A. G. AU - Gorlick, R. AU - Healey, J. H. PY - 2005 DA - 2005// TI - Elevated physiologic tumor pressure promotes proliferation and chemosensitivity in human osteosarcoma JO - Clin Cancer Res VL - 11 UR - https://doi.org/10.1158/1078-0432.CCR-04-2048 DO - 10.1158/1078-0432.CCR-04-2048 ID - Nathan2005 ER - TY - JOUR AU - Baxter, L. T. AU - Jain, R. K. AU - Svensjo, E. PY - 1987 DA - 1987// TI - Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs JO - Microvasc Res VL - 34 UR - https://doi.org/10.1016/0026-2862(87)90066-5 DO - 10.1016/0026-2862(87)90066-5 ID - Baxter1987 ER - TY - JOUR AU - Jain, R. K. AU - Tong, R. T. AU - Munn, L. L. PY - 2007 DA - 2007// TI - Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model JO - Cancer Res VL - 67 UR - https://doi.org/10.1158/0008-5472.CAN-06-4102 DO - 10.1158/0008-5472.CAN-06-4102 ID - Jain2007 ER - TY - JOUR AU - Boucher, Y. AU - Baxter, L. T. AU - Jain, R. K. PY - 1990 DA - 1990// TI - Interstitial pressure gradients in tissue isolated and subcutaneous tissues: implications for therapy JO - Cancer Res VL - 50 ID - Boucher1990 ER - TY - JOUR AU - Tong, R. T. AU - Boucher, Y. AU - Kozin, S. V. AU - Winkler, F. AU - Hicklin, D. J. AU - Jain, R. K. PY - 2004 DA - 2004// TI - Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-04-0074 DO - 10.1158/0008-5472.CAN-04-0074 ID - Tong2004 ER - TY - JOUR AU - Tufto, I. AU - Lyng, H. AU - Rofstad, E. K. PY - 1996 DA - 1996// TI - Interstitial fluid pressure, perfusion rate and oxygen tension in human melanoma xenografts JO - Br J Cancer Suppl VL - 27 ID - Tufto1996 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/8/2/prepub UR - http://www.biomedcentral.com/1471-2407/8/2/prepub ID - ref58 ER -