TY - JOUR AU - Kam, Yoonseok AU - Guess, Cherise AU - Estrada, Lourdes AU - Weidow, Brandy AU - Quaranta, Vito PY - 2008 DA - 2008/07/14 TI - A novel circular invasion assay mimics in vivo invasive behavior of cancer cell lines and distinguishes single-cell motility in vitro JO - BMC Cancer SP - 198 VL - 8 IS - 1 AB - Classical in vitro wound-healing assays and other techniques designed to study cell migration and invasion have been used for many years to elucidate the various mechanisms associated with metastasis. However, many of these methods are limited in their ability to achieve reproducible, quantitative results that translate well in vivo. Such techniques are also commonly unable to elucidate single-cell motility mechanisms, an important factor to be considered when studying dissemination. Therefore, we developed and applied a novel in vitro circular invasion assay (CIA) in order to bridge the translational gap between in vitro and in vivo findings, and to distinguish between different modes of invasion. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-8-198 DO - 10.1186/1471-2407-8-198 ID - Kam2008 ER -