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Table 7 Univariate and multivariate analysis of survival in patients with colorectal cancer.

From: Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer

  Univariate analysis Multivariate analysis
  Log-Rank Test Cox Proportional Hazards Model
Variable P value P value HR (95% CL)
Dukes < 0.0001 0.004 1.88 (1.22–2.89)
PAI-1 0.012 0.001 2.22 (1.21–4.06)
CATB 0.0004 0.042 2.09 (1.02–4.26)
CATL 0.021 0.639 1.17 (0.60–2.29)
CA 19-9 0.004 0.024 1.98 (1.09–3.58)
uPA 0.369    
CEA 0.159    
Grade 0.420    
Location 0.566    
Age 0.247    
Gender 0.122    
  1. Univariate analysis including Dukes classification, cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA, CA 19-9, tumor grade, tumor location, age, and gender. Variables were included in the multivariate analysis only if the P value was less than 0.05 in the univariate analysis. In the multivariate statistical analysis all parameters -including Dukes classification, PAI-1, CATB, CATL and CA 19-9 – were tested in one model.
  2. Abbreviations: Dukes: Dukes classification; CATB: cathepsin B; CATL: cathepsin L; uPA: urokinase-type plasminogen activator, PAI-1: plasminogen activator inhibitor type-1; CEA: carcinoembryonic antigen; CA 19-9: carbohydrate antigen 19-9; Grade: tumor grade (differentiation); Location: tumor location; HR: Hazard ratio; 95% CL: 95% Hazard ratio confidence limits