Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer

Table 7 Univariate and multivariate analysis of survival in patients with colorectal cancer.

	Univariate analysis	Multivariate analysis
	Log-Rank Test	Cox Proportional Hazards Model
Variable	P value	P value	HR	(95% CL)
Dukes	< 0.0001	0.004	1.88	(1.22–2.89)
PAI-1	0.012	0.001	2.22	(1.21–4.06)
CATB	0.0004	0.042	2.09	(1.02–4.26)
CATL	0.021	0.639	1.17	(0.60–2.29)
CA 19-9	0.004	0.024	1.98	(1.09–3.58)
uPA	0.369
CEA	0.159
Grade	0.420
Location	0.566
Age	0.247
Gender	0.122

Univariate analysis including Dukes classification, cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA, CA 19-9, tumor grade, tumor location, age, and gender. Variables were included in the multivariate analysis only if the P value was less than 0.05 in the univariate analysis. In the multivariate statistical analysis all parameters -including Dukes classification, PAI-1, CATB, CATL and CA 19-9 – were tested in one model.
Abbreviations: Dukes: Dukes classification; CATB: cathepsin B; CATL: cathepsin L; uPA: urokinase-type plasminogen activator, PAI-1: plasminogen activator inhibitor type-1; CEA: carcinoembryonic antigen; CA 19-9: carbohydrate antigen 19-9; Grade: tumor grade (differentiation); Location: tumor location; HR: Hazard ratio; 95% CL: 95% Hazard ratio confidence limits

ISSN: 1471-2407