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Table 3 Functional classes of genes enriched in the Met library in comparison to the frequency within the whole set of predicted human genes

From: Suppression subtractive hybridization profiles of radial growth phase and metastatic melanoma cell lines reveal novel potential targets

Functional Class (biological process) Genes Relative enrichment significance
cell adhesion ADAM10, CTGF, CTNNB1, CTNND1, FN1, ITGA6, ITGB1, ITGB8, LAMA4, NRCAM, SPP1, TGFBI, THBS2, TNFAIP6, HMCN1, CD164, NRP2, NRXN3, CD36 O = 19a; E = 6.7b; R = 2.84c; P = 3.71E-05d
cell-matrix adhesion ITGA6, ITGB1, ITGB8, SPP1 O = 4; E = 0.6; R = 6.67; P = 0.0030
regulation of cell adhesion ADAM10, LAMA4, TGFBI, CD164 O = 4; E = 0.4; R = 10; P = 0.00064
integrin-mediated signaling pathway ADAM10, ITGA6, ITGB1, ITGB8 O = 4; E = 0.57; R = 7.02; P = 0.0025
intracellular receptor-mediated signaling pathway CTNNB1, EDD1, RB1, NCOA4 O = 4; E = 0.47; R = 8.51; P = 0.0012
cell differentiation ACVR1C, DCT, GPM6B, MGP, MITF, NRCAM, SERPINE2, SFRP1, SPP1, TYR, TYRP1, NRP2, NRXN3 O = 13; E = 5.34; R = 2.43; P = 0.0027
cell motility CTGF, FN1, ITGB1, LAMA4, NRCAM, SERPINE2, SPP1, NRP2, NRXN3 O = 9; E = 2.42; R = 3.72; P = 0.00072
cell migration FN1, ITGB1, LAMA4, NRCAM, SERPINE2, SPP1, NRP2, NRXN3 O = 8; E = 1.04; R = 7.69; P = 9.41E-06
nucleocytoplasmic transport ADAM10, KPNA1, NPM1, IPO9, G3BP2, THOC1 O = 6; E = 1.25; R = 4.8; P = 0.0016
negative regulation of cell proliferation GPNMB, FABP7, IL6, NPM1, CUL5, CD164 O = 6; E = 1.59; R = 3.77; P = 0.0052
aromatic amino acid family metabolism DCT, TDO2, TYR, TYRP1 O = 4; E = 0.23; R = 17.39; P = 6.642E-05
aromatic compound metabolism CPM, DCT, TDO2, TYR, TYRP1 O = 5; E = 0.97; R = 5.15; P = 0.0028
cofactor biosynthesis PBEF1, TMEM131, TPK1, ATP5A1, ATP6V1B2 O = 5; E = 1.18; R = 4.24; P = 0.0066
coenzyme biosynthesis PBEF1, TMEM131, TPK1, ATP5A1, ATP6V1B2 O = 5; E = 1.04; R = 4.81; P = 0.0039
negative regulation of transcription HMGB1, TRIM33, HBXAP, NKRF, RB1, ARID5B O = 6; E = 1.72; R = 3.49; P = 0.0076
positive regulation of transcription CTNNB1, ILF2, NFATC2, HBXAP, RB1, NCOA4 O = 6; E = 1.19; R = 5.04; P = 0.0012
mRNA processing DHX8, PABPC1, GRSF1, SFRS2, SNRPB2, SNRPG, G3BP2, THOC1 O = 8; E = 2.13; R = 3.76; P = 0.0013
pigment metabolism DCT, TYR, TYRP1 O = 3; E = 0.25; R = 12; P = 0.0018
  1. a: observed number of genes in the category; b: expected number of genes in the category; c: observed/expected ratio; d: p-value of the enrichment significance