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Figure 1 | BMC Cancer

Figure 1

From: Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level

Figure 1

Minimal region of LOH in CRC liver metastases. a. 21 markers between D8S351-D8S1745 on chromosome 8 in matched colon tumour (CT) and liver metastases (LM) for 6 patients. Markers are ordered and oriented with telomeric end top centromeric end bottom. LOH (open circle), retention (closed circle) and Non-informative (line) are indicated. The boxed region indicates markers selected for analysis of larger series of LM samples results shown in Figure 1b. b. Selected markers D8S1786-NEFL on 8p21 in LM for 21 patients. Markers are ordered and oriented with telomeric end top centromeric end bottom. LOH (open circle), retention (closed circle) and Non-informative (line) are indicated. The boxed region highlights the minimal region of loss identified in patient #22. c. Loss of microsatellite marker D8S1181 (arrow) defining the minimal region of loss in patient #22. Retention of markers D8S1734, NEFL and D8S1048 and loss of D8S1181 in tumour (LM liver metastases) compared to normal (B, blood) are shown.d. Metastasis Specific Loss at D8S1181. Gel images illustrating loss (arrow) of D8S1811 in liver metastases (LM) but not matched normal (B, blood) or colon tumour (CT) in 2 patients.

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BMC Cancer

ISSN: 1471-2407

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