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Table 1 Analysis of the effect of MMP-2 siRNA or TIMP-2 overexpression on ameloblastoma cell invasion.

From: Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro

Group

Invaded cells (Cells/Well)

Inhibition rate of invasion

MMP-2siRNA

  

Mock

137 ± 21

0

Lipofectamine

129 ± 18

5.8

pRNA-neg

131 ± 28

4.4

pRNA-MMP-2(1 μg)

116 ± 24*

15.3

pRNA-MMP-2(2 μg)

61 ± 16*

55.5

pRNA-MMP-2(3 μg)

53 ± 20*

61.3

TIMP-2 overexpression

  

Mock

128 ± 18

0

Lipofectamine

123 ± 21

3.9

pcDNA-neg

117 ± 16

8.6

pcDNA-TIMP-2(1 μg)

97 ± 25*

24.2

pcDNA-TIMP-2(2 μg)

59.8 ± 23*

53.3

pcDNA-TIMP-2(3 μg)

63.4 ± 19*

50.5

  1. *Compared with the mock, lipifectamine or vector controls, respectively, P < 0.05.
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BMC Cancer

ISSN: 1471-2407

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