Model building procedure. LS-SVM model building procedure for disease stage, the model building procedure for response to platin-based chemotherapy is similar. First (A), the 3000 genes with the largest degree of differential expression between two classes in the pilot study are selected. Next (B), the corresponding gene expression values are selected in the independent data set. Subsequently, (C) an LS-SVM model is built using only the pilot data. Finally, (D) this model is used to predict the class of the samples in the independent data set which gives an estimate of the generalization performance.