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Table 1 Immunohistochemical expression of Retinoid X receptors and hPXR isoforms in human breast lesions.

From: Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha

 

BBDs (n = 12)

CIS (n = 10)

IDC (n = 54)

ILC (n = 23)

p-value1

 

N

C

N

C

N

C

N

C

N

C

hPXR1.2

0

6 (50%)

0

9 (90%)

15 (27.8%)

54 (100%)

7 (30.4%)

23 (100%)

0.048

<0.001

hPXR1

0

4 (33.4%)

0

8 (80%)

0

54 (100%)

0

23 (100%)

1.000

<0.001

RXR-α

0

1 (8.4%)

0

2 (20%)

23 (42.6%)

25 (46.3%)

11 (47.8%)

8 (34.8%)

0.002

0.037

RXR-β

0

0

0

3 (30%)

8 (14.8%)

30 (55.6%)

2 (8.7%)

12 (52.1%)

0.301

0.003

RXR-γ

0

2 (16.7%)

0

4 (40%)

8 (14.8%)

35 (64.8%)

5 (21.7%)

10 (43.5%)

0.161

0.002

  1. Numbers represent the frequencies and percentages of cases with positive reaction. BBDs: benign breast diseases. CIS: carcinoma in situ. IDC: infiltrative ductal carcinoma. ILC: infiltrative lobular carcinoma. n: number of cases. N: nucleus. C: cytoplasm. 1 p-values obtained by one-way Kruskal-Wallis test to compare overall between pathological groups differences in the degree of staining.