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Figure 3 | BMC Cancer

Figure 3

From: The metastasis-associated protein S100A4 exists in several charged variants suggesting the presence of posttranslational modifications

Figure 3

Charge variants identified as S100A4 by MALDI-TOF, detected tryptic peptides, and location of predicted PTMs. A-C: Schematic representation of the different spots obtained from various sources confirmed as S100A4 by MALDI-TOF and MALDI-TOF/TOF. All shown spots are identified in the SwissProt library as S100A4 with p < 0.05. A: In vitro cultured HCT116. B: Tumor biopsy from a colorectal cancer patient. C: Human recombinant S100A4 produced in-house. D: Representation of the S100A4 amino acid sequence with all tryptic peptides discovered on MALDI-TOF (boxes) and location of phosphorylations (P) and deamidations (D) predicted by computer algorithms.

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BMC Cancer

ISSN: 1471-2407

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