Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

BMC Cancer

Table 1 Comparison of PIK3 CA amplification or p53/p21 protein expression in High Grade Serous Ovarian Tumours

Group	PIK3CA amplification (MIP copy number)	p53/p21 IHC
		+/-	+/+, -/-	-/+
BRCA1 loss through mutation	0/9^*+	4/9	2/9	3/9
BRCA1 epigenetic loss	7/8^*+	8/9**	1/9	0/9
No BRCA1 loss	3/11⁺	3/12**	5/12	4/12

* p = 0.02 for pairwise comparison based on Bonferroni-Holmes corrected Fisher exact test
** p = 0.03 for pairwise comparison based on Bonferroni-Holmes corrected Fisher exact test
+ p = 0.001 for threeway comparison based on Bonferroni-Holmes corrected Fisher exact test

ISSN: 1471-2407