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Table 1 Comparison of PIK3 CA amplification or p53/p21 protein expression in High Grade Serous Ovarian Tumours

From: Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

Group PIK3CA amplification (MIP copy number) p53/p21 IHC
   +/- +/+, -/- -/+
BRCA1 loss through mutation 0/9*+ 4/9 2/9 3/9
BRCA1 epigenetic loss 7/8*+ 8/9** 1/9 0/9
No BRCA1 loss 3/11+ 3/12** 5/12 4/12
  1. * p = 0.02 for pairwise comparison based on Bonferroni-Holmes corrected Fisher exact test
  2. ** p = 0.03 for pairwise comparison based on Bonferroni-Holmes corrected Fisher exact test
  3. + p = 0.001 for threeway comparison based on Bonferroni-Holmes corrected Fisher exact test