Pt number | Sex | Age | Previous adjuvant CT | Type of adjuvant CT | Previous regimen for metastatic disease | Tumor Best response | Time to progression (weeks) | KRAS exon 1 | EGFR exon13 | EGFR copy Number (FISH) |
---|---|---|---|---|---|---|---|---|---|---|
Responders | ||||||||||
1 | F | 70 | 0 | - | PR | 10 | Wild-type | R521K | high polysomy | |
2 | M | 62 | 0 | Folfirinox | PR | 94* | Wild-type | trisomy | ||
3 | F | 56 | 0 | Folfiri, Folfox | PR | 9 | Wild-type | high polysomy | ||
4 | M | 37 | 0 | Folfiri, Folfox, xelox | PR | 44 | Wild-type | low polysomy | ||
5 | F | 44 | 0 | Folfiri, Folfiri | PR | 33 | Wild-type | R521K | disomy | |
6 | F | 54 | 1 | LV5FU | Folfiri | PR | 67 | Gly13Asp | disomy | |
7 | F | 52 | 1 | Fufol | Folfirinox, Folfiri, LV5FU-mitomycine | PR | 42 | Gly12Asp | R521K | disomy |
8 | M | 56 | 0 | Foflfox | PR | 25 | Wild-type | disomy | ||
9 | M | 66 | 1 | Fufol | Folfiri, Folfox | PR | 24* | Wild-type | R521K | trisomy |
Non-responders | ||||||||||
10 | F | 68 | 0 | Folfiri, Xeloda, Xelox | SD | 17 | Wild-type | R521K | trisomy | |
11 | F | 74 | 1 | LV5FU | Folfiri | SD | 10 | Gly12Val | disomy | |
12 | M | 61 | 0 | Folfirinox | SD | 18 | Gly13Asp | R521K | disomy | |
13 | F | 71 | 0 | Xelox Avastin-Xeliri | SD | 15 | Gly12Asp | disomy | ||
14 | M | 59 | 0 | LV5FU, Folfiri, Folfox | SD | 24 | Gly12Cys | R521K | trisomy | |
15 | M | 71 | 0 | Folfox, Irinotecan | SD | 14 | Wild-type | disomy | ||
16 | F | 60 | 1 | Fufol | Folfiri, Folfox, Cape, LV5FU | SD | 17 | Wild-type | trisomy | |
17 | M | 65 | 0 | Folfirinox, Folfiri | SD | 18 | Wild-type | low polysomy | ||
18 | M | 66 | 0 | Folfiri | SD | 17 | Wild-type | R521K | disomy | |
19 | F | 45 | 0 | Folfox, Xelox | SD | 17 | Wild-type | R521K | NE | |
20 | F | 42 | 0 | Folfirinox | SD | 21 | Gly12Asp | R521K | trisomy | |
21 | M | 62 | 1 | Folfox | Xeliri | SD | 36 | Gly13Asp | R521K | disomy |
22 | M | 58 | 1 | Folfiri | Xelox, Xeliri | PD | NA | Gly13Asp | disomy | |
23 | M | 75 | 1 | Xelox | Xeliri | PD | NA | Wild-type | trisomy | |
24 | M | 81 | 0 | Xelox, Folfiri | PD | NA | Gly12Val | disomy | ||
25 | F | 55 | 0 | Xelox Avastin-Xeliri | PD | NA | Gly12Asp | disomy | ||
26 | M | 60 | 1 | LV5FU | Folfiri, Folfiri, Folfox | PD | NA | Wild-type | NE | |
27 | M | 59 | 0 | Folfiri, Folfiri/Folfox, Folfox | PD | NA | Gly12Asp | NE | ||
28 | F | 58 | 1 | LV5FU | Folfiri, Xelox | PD | NA | Gly12Asp | disomy | |
29 | M | 51 | 0 | Folfox, Folfiri | PD | NA | Wild-type | disomy | ||
30 | F | 66 | 0 | Folfiri, Xelox | PD | NA | Wild-type | R521K | trisomy | |
31 | F | 56 | 0 | - | PD | NA | Wild-type | disomy | ||
32 | F | 78 | 0 | Folfox, Folfiri, Cape | PD | NA | Gly12Val | disomy |