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Table 4 Validated pathways with significant differential expression between N0 and N+ HNSCC

From: Gene-expression of metastasized versus non-metastasized primary head and neck squamous cell carcinomas: A pathway-based analysis

Pathways

Genes in pathway

Probes in reference dataset (n)

Probes in validation dataset (n)

p-value

p-value (FDR adjusted)

MAPK 1/3 regulated MMPs

16

17

14

0.003

0.028

JNK/MAPK regulated MMPs

25

28

19

0.003

0.028

MAPK 1/3 regulated invasion

35

38

30

0.004

0.028

MMPs

9

8

8

0.005

0.028

HIF1α regulated invasion

14

11

11

0.011

0.048

HIF1α regulated angiogenesis

26

21

19

0.013

0.048

uPA system

3

3

2

0.015

0.048

  1. Genes in pathway = number of genes theoretically involved in the pathway. Probes in reference dataset = number of probes representing pathway genes in the reference dataset. Probes in validation dataset = number of probes representing pathway genes in the validation dataset. P-value = raw p-value of the global test. P-value (FDR adjusted) = p-value of the global test, corrected for multiple testing using the false discovery rate. Differentially expressed pathways are considered to be validated by the validation dataset if the FDR adjusted p-value is smaller than 0.05.