Figure 1

Heatmap of pathways with validated differential gene expression between non-metastasized and metastasized primary HNSCC. Each row in the figure denotes a gene and each column denotes a sample. Panel on the left: validated differentially expressed pathways in the reference study. Panel on the right: validated differentially expressed pathways in the validation study. Relative gene-expression is shown for each gene in the pathway, and for each sample in the N0 and N1 HNSCC subgroups, red indicating overexpression and green indicating underexpression. White brackets indicate genes not represented on the respective microarray platforms.