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Table 2 Clinicopathological characteristics, LOH and gene expression variation in folds* for 16 tumor samples.

From: Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma

Sample (Patient) no. Age (yrs)/Sex Tumor classification Metastasis Tobacco use LOH@ TSC1 LOH@ TSC2 TSC1 (D) TSC2 (D) AKT1 (U) PIK3C2A (U) PDPK1 (U) RHEB (U) FRAP1 (U) RPS6KB1 (U) RPS6 (U) EIF4E (U) EIF4EBP1(D) PTEN (D)
54 40 M T4N1M0 N/A Yes - - 1.39 2.04 2.04 2.34 0.77 2.29 1.82 2.25 3.40 2.23 3.12 1.70
39 55 F T4N1M0 Yes Yes - - 1.77 1.95 4.04 2.47 2.33 1.92 2.68 3.34 2.67 3.01 0.98 1.44
19 48 F T4N2bM0 No Yes - - 1.93 3.57 3.29 1.63 1.57 2.12 2.21 2.93 2.01 2.07 1.45 2.04
15 55 F T3N1M0 No Yes - - 2.63 2.03 4.68 3.23 1.81 0.76 1.76 1.48 2.83 1.31 3.03 2.35
20 50 F T4N1M0 Yes Yes - - 1.98 2.03 1.46 1.65 0.65 0.85 0.92 1.34 1.50 1.98 3.02 1.87
8 50 F T3N1M0 No Yes - - 1.15 1.37 1.57 0.95 1.39 1.73 0.44 0.61 0.64 1.54 4.27 3.67
11 60 F T4N1Mx Yes Yes - - 0.31 0.69 1.80 1.69 1.03 2.54 3.76 1.94 0.69 1.17 0.96 2.36
40 50 F T2N1M0 Yes Yes + - 2.33 1.48 1.75 2.16 1.90 2.22 2.82 6.25 1.83 4.22 2.06 1.60
50 40 M T4N2bM0 Yes Yes - - 1.20 2.98 1.34 0.58 1.43 1.22 1.25 2.45 2.69 1.50 3.67 1.35
52 70 M ED N/A No - - 2.35 1.82 2.69 2.64 1.50 2.23 5.78 1.80 1.76 3.74 1.69 2.23
32 35 M T4N0Mx No Yes - - 1.58 3.03 2.04 0.90 1.15 0.80 1.48 1.67 1.89 1.60 2.24 1.18
53 38 F T2N0M0 No Yes + - 7.92 1.51 3.68 2.88 2.59 2.78 1.19 2.32 1.21 2.13 2.77 1.99
55 40 F T4N1M0 Yes Yes + - 1.35 1.81 2.27 2.99 1.53 1.70 12.4 1.37 4.47 2.67 1.77 1.46
57 62 F T1N0M0 Yes Yes - - 1.40 2.39 2.26 4.50 8.26 2.95 2.24 5.05 1.80 2.32 2.17 0.50
59 70 F T4N2bM0 Yes Yes - + 2.38 1.30 1.48 2.80 1.92 1.67 1.38 0.67 1.66 1.70 5.07 1.23
60 40 F T4aN1Mx Yes Yes - - 1.37 1.80 0.87 2.28 1.49 1.98 1.05 1.04 1.99 1.88 0.60 1.30
  1. * We defined the cutoff value for determining the upregulation or downregulation of a gene in a tumor sample as ≥ 1.8 fold difference in its expression between normal and tumor samples [3]. With this criterion, TSC1, TSC2, EIF4EBP1 and PTEN genes showed downregulation in 7/16, 11/16, 10/16 and 7/16 tumor samples, respectively. Whereas AKT1, PIK3C2A, PDPK1, RHEB, FRAP1, RPS6KB1, RPS6 and EIF4E showed upregulation in 10/16, 10/16, 6/16, 9/16, 8/16, 9/16, 10/16 and 10/16 tumor samples, respectively.
  2. Abbreviations: TNM, Tumor, Node, Metastasis; and ED, Epithelial dysplasia.
  3. 'Yes' in tobacco use refers to addiction to tobacco, bidi and cigarettes for at least 15–20 years. '+' denotes LOH found; '-' denotes no LOH; N/A, not applicable;
  4. (D)denotes downregulation of gene expression and (U)denotes upregulation of gene expression across 16 tumor samples.