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Figure 1 | BMC Cancer

Figure 1

From: Antisense oligonucleotides and all-trans retinoic acid have a synergistic anti-tumor effect on oral squamous cell carcinoma

Figure 1

The effect of the treatment with antisense oligonucleotide against hTR(As-ODN-hTR), all-trans retinoic acid (ATRA) on the growth of OSCC tumor xenografts in nude mice. A, tumor growth curve is showed. B, tumor weight is given as the mean ± SE (bars) (n = 10). C, representative mice and tumors in each experimental group is shown at the end of treatment (L = left side, R = right side). Both As-ODN and ATRA treatment resulted in an inhibition of tumor volume and tumor weight as compared to control group. * P < 0.01, one-way ANOVA. In addition, highly significant interactions exist between hTR As-ODN and ATRA. * * F = 10.743, P = 0.002, two-way ANOVA. The combination of As-ODN and ATRA resulted in a significant enhancement of the reduction in tumor growth when compared with monotherapy of As-ODN or ATRA alone (P < 0.01).

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