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Figure 6 | BMC Cancer

Figure 6

From: Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer

Figure 6

Sequence analysis of Vav3 and Vav1 genes. (A) The consensus sequences of LXXLL motifs I, II, and III were identified in the DH domain of Vav3 as indicated. Mutation of LLLQELV sequence overlapping with LXXLL motifs II and III has been shown to abolish the GEF activity of Vav3. (B) A consensus sequence of the nucleus localization signal (NLS) in Vav3 was localized in the PH domain.

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