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Table 2 Proportion of predictive tests positive in unaffected FDR women >50 years of age by family Manchester score for each gene

From: Penetrance estimates for BRCA1 and BRCA2based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family

Manch score predictives

Above or =

Below

(score)

% positive

% positive

BRCA2 >50 (23)

9/37 (24%)

9/24 (37.5%)

BRCA2 >50 (20)

10/44 (23%)*

8/17 (47%)*

BRCA1 >50 (23)

7/33 (21%)

5/20 (20%)

BRCA1 >50 (20)

8/39 (20.5%)

4/14 (29%)

  1. *chi square for difference 3.48; p = 0.07