From: Penetrance estimates for BRCA1 and BRCA2based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family
Manch score predictives
Above or =
Below
(score)
% positive
BRCA2 >50 (23)
9/37 (24%)
9/24 (37.5%)
BRCA2 >50 (20)
10/44 (23%)*
8/17 (47%)*
BRCA1 >50 (23)
7/33 (21%)
5/20 (20%)
BRCA1 >50 (20)
8/39 (20.5%)
4/14 (29%)