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Table 2 Proportion of predictive tests positive in unaffected FDR women >50 years of age by family Manchester score for each gene

From: Penetrance estimates for BRCA1 and BRCA2based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family

Manch score predictives Above or = Below
(score) % positive % positive
BRCA2 >50 (23) 9/37 (24%) 9/24 (37.5%)
BRCA2 >50 (20) 10/44 (23%)* 8/17 (47%)*
BRCA1 >50 (23) 7/33 (21%) 5/20 (20%)
BRCA1 >50 (20) 8/39 (20.5%) 4/14 (29%)
  1. *chi square for difference 3.48; p = 0.07