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Table 1 Proportion of living unaffected FDR females undertaking presymptomatic predictive genetic testing by gene and age cohort.

From: Penetrance estimates for BRCA1 and BRCA2based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family

Predictive test result By age

BRCA1 +ve

BRCA1-ve

Number positive BRCA1

BRCA1 untested

BRCA2 +ve

BRCA2-ve

Number positive BRCA2

BRCA2 untested

Proportion positive BRCA1 assumed

Proportion positive BRCA2 assumed

18–30 yrs

28

34

28/62 (45%)

41

18

19

18/37 (48%)

34

50%

50%

30–39 yrs

51

42

51/93 (55%)

78

50

41

50/91 (55%)

64

50%

50%

40–49

22

44

22/66 (33%)

57

34

27

34/61 (56%)

49

33%

50%

50–59

10

19

10/29 (34%)

43

14

21

14/35 (40%)

59

33%

40%

60+

2

24

2/26 (8%)

60

4

19

4/23 (17%)

69

10%

20%

Total

113

163

103/266

279

110

127

110/240

247