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Table 1 Proportion of living unaffected FDR females undertaking presymptomatic predictive genetic testing by gene and age cohort.

From: Penetrance estimates for BRCA1 and BRCA2based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family

Predictive test result By age BRCA1 +ve BRCA1-ve Number positive BRCA1 BRCA1 untested BRCA2 +ve BRCA2-ve Number positive BRCA2 BRCA2 untested Proportion positive BRCA1 assumed Proportion positive BRCA2 assumed
18–30 yrs 28 34 28/62 (45%) 41 18 19 18/37 (48%) 34 50% 50%
30–39 yrs 51 42 51/93 (55%) 78 50 41 50/91 (55%) 64 50% 50%
40–49 22 44 22/66 (33%) 57 34 27 34/61 (56%) 49 33% 50%
50–59 10 19 10/29 (34%) 43 14 21 14/35 (40%) 59 33% 40%
60+ 2 24 2/26 (8%) 60 4 19 4/23 (17%) 69 10% 20%
Total 113 163 103/266 279 110 127 110/240 247