Figure 3From: Penetrance estimates for BRCA1 and BRCA2based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family Cumulative risk of breast cancer by age cohort for BRCA1 and BRCA2 combined after exclusion of the index case. Risk to 40 years: Group 1 (birth year <1900; n = 45) 4%; Group 2 (1900–1920; n = 154) 8%; Group 3 (1920–1930; n = 154) 10%; Group 4 (1930–1940; n = 124) 17%; Group 5 (1940–1950; n = 162) 21%; Group 6 (1950–1960; n = 265) 23%; Group 7 (1960+; n = 276) 22%. Log rank (df 6) 153; p = 0.0005.Back to article page