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Table 3 Univariate analysis of clinicopathological parameters influencing recurrence-free survival (RFS) and overall survival (OS)

From: Promoter methylation-associated loss of ID4expression is a marker of tumour recurrence in human breast cancer

Variable RFS OS
  na events P-valued n events P-value
Clinicopathological factors:       
Tumour sizeb       
   pT1 44 14 0.142 45 7 0.396
   pT2-4 77 35   79 16  
Lymph node statusb       
   pN0 55 11 0.021 54 6 0.033
   pN1-3 59 24   59 15  
Histological grade       
   G1 11 3 0.018 10 1 0.019
   G2 60 15   58 7  
   G3 60 30   54 17  
Histological type       
   invasive ductal 107 33 0.006 106 23 0.877
   invasive lobular 18 9   18 2  
   other 9 7   9 2  
Oestrogen receptor status       
   negative (IRSc 0–2) 46 15 0.701 45 12 0.027
   positive (IRS 3–12) 82 32   82 14  
Progesterone receptor status       
   negative (IRSc 0–2) 43 18 0.240 43 11 0.059
   positive (IRS 3–12) 85 29   84 15  
ID4 promoter methylation       
   negative 39 8 0.036 39 5 0.169
   positive 76 28   75 16  
  1. aOnly female patients with primary, unilateral, invasive breast cancer were included. bAccording to TNM classification by Sobin and Wittekind [37]. c IRS = Immuno-reactive score according to Remmele and Stegner [38]. dFisher's exact test. Significant P-values are marked in bold face.