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Table 1 Results of meta-analysis of expression of Bcl-2 and outcome in Breast Cancer.

From: Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer

Endpoint and meta-analysis model

Estimate of Relative Hazard

Homogeneity Test

  

(95% CI)

p

Q (df)

p

Unadjusted Disease-Free Survival (8 studies, n = 2285)

   Fixed

1.5

(1.3–1.7)

<0.001

22.4 (7)

0.002

   Random

1.7

(1.3–2.2)

<0.001

  

   Fixed *

1.7

(1.5–2.0)

<0.001

6.6 (6)

0.360

   Random*

1.7

(1.5–2.1)

<0.001

  

Adjusted Disease-Free Survival (11 studies, n = 2128)

   Fixed

1.5

(1.3–1.7)

<0.001

17.2 (10)

0.07

   Random

1.6

(1.3–2.0)

<0.001

  

Unadjusted Overall Survival (8 studies, n = 3910)

   Fixed

1.6

(1.4–1.7)

<0.001

17.5 (7)

0.015

   Random

1.6

(1.4–2.0)

<0.001

  

   Fixed *

1.6

(1.5–1.8)

<0.001

10.0 (6)

0.126

   Random*

1.7

(1.5–2.0)

<0.001

  

Adjusted Overall Survival (9 studies, n = 3624)

   Fixed

1.3

(1.2–1.4)

<0.001

15.5 (8)

0.050

   Random

1.4

(1.2–1.6)

<0.001

  
  1. * values after exclusion of the study by Motolesse et al. [31] (n = 157)