From: Characterization of three new serous epithelial ovarian cancer cell lines
Cell line growth assays | TOV-1946 | OV-1946 | TOV-2223 | TOV-112D | |
---|---|---|---|---|---|
Growth characteristic | Doubling time (days) +/- S.D.a | 1.3 +/- 0.4 | 2.5 +/- 0.9 | 2.6 +/- 0.7 | 1.0 +/- 0.2 |
 | Saturation density (nb cells +/- S.D.)b | 3 053 933 +/- 153 933 | 3 231 400 +/- 962 723 | 2 536 867 +/-680 852 | 6 162133 +/- 515 034 |
 | Number of passages to date | >210 | >210 | >150 | >200 |
Spheroid | Formation | aggregate | semi-compact | no | compact |
Migration | time for wound filling (h) | 24 | 48 | >48 | 48 |
Invasion | Mean number of cells +/- S.D.c | 417 +/- 226 | 149 +/- 70 | 257 +/- 79 | 118 +/- 34 |
Soft agarose | Colony number +/- S.D.d | 11 +/- 3 | 24 +/- 8 | 16 +/- 4 | 27 +/- 10 |
 | Colony size | large | large | small | large |
Low serum | Capacity to grow in low serum (1%) conditions | yes | yes | yes | yes |
Subcutaneous injection in SCID mice | Number of mice with tumors (n = 6) | 0 | 0 | 0 | 5 |
 | Mean time of tumor appearance (days) | N/A | N/A | N/A | 7 |
Intraperitoneal injection in SCID mice | Number of mice with tumors (n = 6) | 3 | 5 | 0 | 6 |
 | Mean time of tumor appearance (days) | 125 | 63 | N/A | 18 |
 | Number of mice with ascitis | 2 | 1 | 0 | 2 |