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Figure 4 | BMC Cancer

Figure 4

From: Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model

Figure 4

Total plasma antioxidant capacity and tumour APE/Ref-1 expression. (A) Plasma samples from mice exposed to AH showed a trend of reduced levels of total antioxidant reductive capacity relative to AC mice. (B) Scatter plot of total antioxidant reductive capacity and 8-oxo-dG lesions in matching samples showed a significant positive correlation for AC mice (r2 = 0.9094; P < 0.05), which was absent in the AH samples (r2 = 0.008383; P = 0.8836). (C) BER protein, APE/Ref-1 was expressed predominantly in the connective tissue of the MMTV-PyMT tumours. (D) Total positive staining area for APE/Ref-1 in tumour tissue (excluding connective tissue) did not differ in tissues from acute hypoxia and air control exposed mice. Bars: median with interquartile range. Scale bar: 50 μm.

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