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Figure 3 | BMC Cancer

Figure 3

From: Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model

Figure 3

Primary and metastatic tumour progression in MDA- and AH – exposed mice. (A) CC mice developed significantly larger primary tumours than mice exposed to AH (P < 0.001; ***) or AC conditions (P < 0.01; **). Six-week exposure to MDA did not affect the size of endpoint tumour burden relative to MDA-CC. (B) MDA or AH exposure during primary tumour development did not increase macroscopic lung metastases relative to their respective controls. (C) A trend towards an increased number of micrometastases was seen following MDA consumption. Micrometastases were not assessed in the hypoxia experiment due to a large number of macroscopic metastases. Abbreviations: MDA = malondialdehyde (n = 28) and MDA-CC = cage controls for MDA group (n = 30), 81 days; AH = acute hypoxia (n = 24), AC = air control (n = 26) and CC = cage controls for AH group (n = 20), 88 days. Bars: mean with SEM (A), medians (B and C). Number of animals used for each group is indicated in parentheses.

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