| | |
Time to progression
|
Overall survival
|
|---|
| | |
Median TTP (Mo)*
|
HR#
|
95% CI
|
p-value#
|
Median OS (Mo)*
|
HR#
|
95% CI
|
p-value#
|
|
Age
|
≤ 55
|
5.6
|
1.000
| |
0.485
|
11.9
|
1.000
| |
0.146
|
| |
> 55
|
5.0
|
0.840
|
0.514–1.371
| |
10.8
|
1.610
|
0.847–3.060
| |
|
Performance
|
ECOG 0–1
|
6.0
|
1.000
| |
0.042
|
12.6
|
1.000
| |
0.124
|
| |
ECOG 2
|
3.7
|
1.892
|
1.022–3.501
| |
10.0
|
1.722
|
0.862–3.441
| |
|
Histotype
|
Intestinal
|
6.1
|
1.000
| |
0.495
|
14.5
|
1.000
| |
0.392
|
| |
Diffuse
|
5.6
|
1.197
|
0.714–2.009
| |
10.8
|
1.337
|
0.687–2.602
| |
|
Disease status
|
Initial stage IV
|
5.6
|
1.000
| |
0.362
|
12.6
|
1.000
| |
0.903
|
| |
Relapsed
|
6.0
|
1.288
|
0.748–2.219
| |
10.8
|
0.959
|
0.489–1.881
| |
|
TS 5'UTR
|
2R/2R, 2R/3C, 3C/3C
|
5.6
|
1.000
| |
0.781
|
10.8
|
1.000
| |
0.244
|
| |
2R/3G, 3C/3G, 3G/3G
|
6.1
|
0.781
|
0.415–1.470
| |
17.4
|
0.669
|
0.340–1.316
| |
|
TS 6-bp deletion in 3'UTR
|
+6/+6 or +6/-6
|
4.7
|
1.000
| |
0.033
|
10.3
|
1.000
| |
0.046
|
| |
-6/-6
|
6.3
|
0.572
|
0.342–0.956
| |
17.8
|
0.536
|
0.291–0.988
| |
|
GSTP1-Ile105Val
|
A/A
|
6.0
|
1.000
| |
0.398
|
11.9
|
1.000
| |
0.621
|
| |
A/G or G/G
|
6.3
|
1.243
|
0.750–2.061
| |
14.5
|
0.621
|
0.452–1.606
| |
|
ERCC-Asn118Asn
|
C/C
|
6.2
|
1.000
| |
0.433
|
14.5
|
1.000
| |
0.472
|
| |
C/T or T/T
|
5.0
|
0.822
|
0.503–1.342
| |
11.9
|
1.251
|
0.680–2.302
| |
|
ERCC-C8092A
|
C/C
|
6.1
|
1.000
| |
0.826
|
17.8
|
1.000
| |
0.326
|
| |
C/A or A/A
|
5.6
|
0.945
|
0.569–1.568
| |
11.4
|
1.356
|
0.739–2.490
| |
|
XPD- Arg156Arg
|
C/C
|
4.1
|
1.000
| |
0.022
|
10.5
|
1.000
| |
0.355
|
| |
C/A or A/A
|
6.2
|
0.533
|
0.311–0.913
| |
14.5
|
0.738
|
0.367–1.405
| |
|
XPD-Asp312Asn
|
G/G
|
6.1
|
1.000
| |
0.084
|
14.0
|
1.000
| |
0.673
|
| |
G/A
|
3.5
|
1.942
|
0.914–4.129
| |
10.8
|
0.800
|
0.283–2.256
| |
|
XPD-Lys751Gln
|
A/A
|
6.1
|
1.000
| |
0.693
|
12.6
|
1.000
| |
0.173
|
| |
A/C or C/C
|
4.6
|
0.872
|
0.440–1.725
| |
Not reached
|
0.488
|
0.174–1.369
| |
|
XRCC1-Arg399Gln
|
G/G
|
6.1
|
1.000
| |
0.744
|
15.3
|
1.000
| |
0.160
|
| |
G/A or A/A
|
5.9
|
1.090
|
0.649–1.832
| |
10.3
|
1.575
|
0.835–2.971
| |
- Mo, months; HR, hazard ratio; CI, confidence interval.
- * By Kaplan-Meier analysis
-
#By Cox proportional hazard regression model, adjusted for performance
- Note: If the hazard ratio is greater than 1, the hazard ratio can be thought of as the average increased risk of progression, or death at any point in time, compared with the reference group (described above line).
