Skip to main content

Table 6 Comparison of TTP and OS according to the clinical factors and genotypes

From: Modified FOLFOX-6 chemotherapy in advanced gastric cancer: Results of phase II study and comprehensive analysis of polymorphisms as a predictive and prognostic marker

   Time to progression Overall survival
   Median TTP (Mo)* HR# 95% CI p-value# Median OS (Mo)* HR# 95% CI p-value#
Age ≤ 55 5.6 1.000   0.485 11.9 1.000   0.146
  > 55 5.0 0.840 0.514–1.371   10.8 1.610 0.847–3.060  
Performance ECOG 0–1 6.0 1.000   0.042 12.6 1.000   0.124
  ECOG 2 3.7 1.892 1.022–3.501   10.0 1.722 0.862–3.441  
Histotype Intestinal 6.1 1.000   0.495 14.5 1.000   0.392
  Diffuse 5.6 1.197 0.714–2.009   10.8 1.337 0.687–2.602  
Disease status Initial stage IV 5.6 1.000   0.362 12.6 1.000   0.903
  Relapsed 6.0 1.288 0.748–2.219   10.8 0.959 0.489–1.881  
TS 5'UTR 2R/2R, 2R/3C, 3C/3C 5.6 1.000   0.781 10.8 1.000   0.244
  2R/3G, 3C/3G, 3G/3G 6.1 0.781 0.415–1.470   17.4 0.669 0.340–1.316  
TS 6-bp deletion in 3'UTR +6/+6 or +6/-6 4.7 1.000   0.033 10.3 1.000   0.046
  -6/-6 6.3 0.572 0.342–0.956   17.8 0.536 0.291–0.988  
GSTP1-Ile105Val A/A 6.0 1.000   0.398 11.9 1.000   0.621
  A/G or G/G 6.3 1.243 0.750–2.061   14.5 0.621 0.452–1.606  
ERCC-Asn118Asn C/C 6.2 1.000   0.433 14.5 1.000   0.472
  C/T or T/T 5.0 0.822 0.503–1.342   11.9 1.251 0.680–2.302  
ERCC-C8092A C/C 6.1 1.000   0.826 17.8 1.000   0.326
  C/A or A/A 5.6 0.945 0.569–1.568   11.4 1.356 0.739–2.490  
XPD- Arg156Arg C/C 4.1 1.000   0.022 10.5 1.000   0.355
  C/A or A/A 6.2 0.533 0.311–0.913   14.5 0.738 0.367–1.405  
XPD-Asp312Asn G/G 6.1 1.000   0.084 14.0 1.000   0.673
  G/A 3.5 1.942 0.914–4.129   10.8 0.800 0.283–2.256  
XPD-Lys751Gln A/A 6.1 1.000   0.693 12.6 1.000   0.173
  A/C or C/C 4.6 0.872 0.440–1.725   Not reached 0.488 0.174–1.369  
XRCC1-Arg399Gln G/G 6.1 1.000   0.744 15.3 1.000   0.160
  G/A or A/A 5.9 1.090 0.649–1.832   10.3 1.575 0.835–2.971  
  1. Mo, months; HR, hazard ratio; CI, confidence interval.
  2. * By Kaplan-Meier analysis
  3. #By Cox proportional hazard regression model, adjusted for performance
  4. Note: If the hazard ratio is greater than 1, the hazard ratio can be thought of as the average increased risk of progression, or death at any point in time, compared with the reference group (described above line).