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Table 2 Association between plasma IGFBP-3 or colonic tissue IGFBP-3 and colorectal adenomas

From: Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas

Plasma IGFBP-3

Cases/Controls (n)

Unadjusted1 OR (95% CI)

Adjusted1,2 OR (95% CI)

P

Quartile4 4

44/110

1.0 (Reference)

1.0 (Reference)

 

Quartile 3

44/109

1.0 (0.6, 1.7)

0.9 (0.5, 1.7)

 

Quartile 2

37/109

0.9 (0.5, 1.5)

0.9 (0.5, 1.7)

 

Quartile 1

47/109

1.1 (0.7, 1.8)

1.0 (0.5, 1.9)

 

P for linear trend

 

0.99

0.88

 

Tissue IGFBP-3

Cases/Controls (n)

Unadjusted1 OR (95% CI)

Adjusted1,3 OR (95% CI)

 

Quartile 4

30/105

1.0 (Reference)

1.0 (Reference)

 

Quartile 3

44/105

1.5 (0.9, 2.5)

1.5 (0.8, 2.8)

 

Quartile 2

43/103

1.5 (0.9, 2.5)

1.7 (0.9, 3.1)

 

Quartile 1

47/103

1.6 (0.9, 2.7)

1.8 (0.9, 3.3)

 

P for linear trend

 

0.07

0.06

 
  1. 1 Odds ratio (OR) and 95% confidence interval (CI); odds of having colorectal adenomas.
  2. 2 Adjusted for waist/hip ratio and alcohol intake for Plasma IGFBP-3.
  3. 3 Adjusted for sex and total calcium for Tissue IGFBP-3.
  4. 4 Quartile cut points based on distribution of IGFBP-3 levels among control subject. The highest quartile is considered as reference.
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BMC Cancer

ISSN: 1471-2407

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