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Table 2 Association between plasma IGFBP-3 or colonic tissue IGFBP-3 and colorectal adenomas

From: Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas

Plasma IGFBP-3 Cases/Controls (n) Unadjusted1 OR (95% CI) Adjusted1,2 OR (95% CI) P
Quartile4 4 44/110 1.0 (Reference) 1.0 (Reference)  
Quartile 3 44/109 1.0 (0.6, 1.7) 0.9 (0.5, 1.7)  
Quartile 2 37/109 0.9 (0.5, 1.5) 0.9 (0.5, 1.7)  
Quartile 1 47/109 1.1 (0.7, 1.8) 1.0 (0.5, 1.9)  
P for linear trend   0.99 0.88  
Tissue IGFBP-3 Cases/Controls (n) Unadjusted1 OR (95% CI) Adjusted1,3 OR (95% CI)  
Quartile 4 30/105 1.0 (Reference) 1.0 (Reference)  
Quartile 3 44/105 1.5 (0.9, 2.5) 1.5 (0.8, 2.8)  
Quartile 2 43/103 1.5 (0.9, 2.5) 1.7 (0.9, 3.1)  
Quartile 1 47/103 1.6 (0.9, 2.7) 1.8 (0.9, 3.3)  
P for linear trend   0.07 0.06  
  1. 1 Odds ratio (OR) and 95% confidence interval (CI); odds of having colorectal adenomas.
  2. 2 Adjusted for waist/hip ratio and alcohol intake for Plasma IGFBP-3.
  3. 3 Adjusted for sex and total calcium for Tissue IGFBP-3.
  4. 4 Quartile cut points based on distribution of IGFBP-3 levels among control subject. The highest quartile is considered as reference.
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