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Table 2 Summary of EGFR mutations detected by sequencing from the 200 NSCLC samples

From: High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies

Exon

Mutation type

Nucleotide Change

AA change

N

18

missense

c.2126A>C

p.E709A

1

  

c.2155G>A *

p.G719S

1

  

c.2156G>C

p.G719A

1

  

c.2170G>A *

p.G724S

1

 

deletion/insertion

c.2127_2130del4insC

p.E709_T710delinsD

1

19

deletion/insertion

c.2233_2245del15

p.K745_D749del

1

  

c.2235_2249del15

p.E746_A750del

19

  

c.2235_2249del15insTTC

p.E746_A750delinsF

1

  

c.2236_2250del15

p.E746_A750del

9

  

c.2237_2251del15

p.E746_A750del

1

  

c.2237_2252del16insT

p.E746_A750delinsV

2

  

c.2237_2238ins18

p.E746VinsPVAIKE

1

  

c.2239_2248del10insC

p.L747_D749delinsP

1

  

c.2239_2251del13insC

p.L747_T751delinsP

1

  

c.2239_2258del20insCA

p.L747_P753delinsQ

1

  

c.2240_2254del15

p.L747_T751del

2

  

c.2240_2257del18

p.L747_P753delinsS

6

  

c.2252_2276del25insA

p.T751_I759delinsN

1

20

missense

c.2303G>T

p.S768I

3

 

deletion/insertion

c.2300_2308del9

p.A767_V769del

1

  

c.2309_2310insCCAGCGTGG

p.D770_H773insGSVD

1

  

c.2311A>G, 2312_2313insGGT

p.N771_P772insGY

1

  

c.2317delCinsTACAACCCCT

p.H773_R776insYNPY

1

  

c.2322_2323insCCACGT

p.C775_R776insPA

1

 

silent mutation

c.2289C>T

p.A763A

1

  

c.2313C>T

p.N771N

1

21

missense

c.2506C>T

p.R836C

1

  

c.2573T>G

p.L858R

13

 

Total

  

75

  1. 75 mutations were seen in 73 patients. AA: amino acid, N: number of samples.
  2. * These samples showed an additional exon 20 c.2303G>T (p.S768I) mutation.
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BMC Cancer

ISSN: 1471-2407

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