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Figure 3 | BMC Cancer

Figure 3

From: High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies

Figure 3

Difference plots and sequence traces for EGFR exons 20 and 21. Panel A: The difference plot of EGFR HRM exon 20a shows different melting profiles of three positive samples (TX53 in red, TX383 in brown and TX440 in orange). Panel B: A p.S768I in TX53, a p.H773_R776insYNPY in TX383 and a p.D770_H773insGSVD in TX440 mutation are detected by sequencing from the HRM positive samples. Panel C: The difference plot of EGFR HRM exon 21 shows three HRM positive samples (TX23 in red, TX44 in purple and TX324 in orange). Panel D: Sequencing chromatograms show a p.R836R SNP in TX23, a p.R836C in TX44 and a p.L858R mutation in TX324.

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