A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population

Table 4 CDH1 intron 2 haplotype frequencies among DGA cases and controls

	Case (freq)^†	Control (freq)^†	Fisher's p	Pearson's p	OR (95%CI)
AAC*	16.04 (0.060)	5.31 (0.027)	0.088	0.088	2.33 (0.86–6.34)
AAG	17.49 (0.065)	5.34 (0.027)	0.056	0.056	2.55 (0.95–6.83)
ATC	73.09 (0.273)	35.43 (0.177)	0.015	0.015	1.74 (1.11–2.74)
ATG	45.38 (0.169)	29.91 (0.150)	0.565	0.565	1.16 (0.70–1.92)
GAC	21.73 (0.081)	24.18 (0.121)	0.152	0.152	0.64 (0.35–1.18)
GAG	17.75 (0.066)	22.17 (0.111)	0.087	0.087	0.57 (0.30–1.09)
GTC	39.15 (0.146)	53.07 (0.265)	0.001	0.001	0.47 (0.30–0.75)
GTG	37.37 (0.139)	24.85 (0.123)	0.602	0.602	1.16 (0.67–1.99)

*Haplotype order: 163+37235G>A, 163+37276T>A, 163+49526C>G. The two 5'-variants were not included, as they did not further split up the haplotypes.
^†Numbers refer to reconstructed haplotype numbers among cases (257) and controls (192), with each individual carrying two chromosomes. Relative frequencies are given in percent. Not all genotype data was included into analysis, as low frequency haplotypes were dropped.

ISSN: 1471-2407