A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population

Table 3 Adjusted ORs associated with the CDH1 intron 2 163+37235G>A variant

Variable		163+37235	Cases		Controls		OR (95% CI)
			n	%	n	%
Age	≤ Median	GG	17	20	20	34	1
		GA	37	45	30	52	1.45 (0.65–3.25)
		AA	29	35	8	14	4.26 (1.55–11.77)
	> Median	GG	13	25	17	40	1
		GA	19	37	20	48	1.24 (0.48–3.24)
		AA	19	37	5	12	4.97 (1.47–16.86)
Sex	Female	GG	13	20	20	34	1
		GA	28	44	30	51	1.44 (0.60–3.42)
		AA	23	36	9	15	3.93 (1.39–11.12)
	Male	GG	17	24	17	41	1
		GA	28	40	20	49	1.40 (0.58–3.39)
		AA	25	36	4	10	6.25 (1.79–21.84)
Smoking	Never	GG	17	24	25	42	1
		GA	30	42	30	50	1.47 (0.66–3.26)
		AA	25	35	5	8	7.35 (2.34–23.01)
	Ever	GG	13	21	12	30	1
		GA	26	42	20	50	1.20 (0.45–3.19)
		AA	23	37	8	20	2.65 (0.86–8.16))
Alcohol	≤ 20 g/day	GG	24	26	26	40	1
		GA	35	38	31	48	1.22 (0.59–2.55)
		AA	34	37	8	12	4.60 (1.78–11.90)
	> 20 g/day	GG	6	15	11	31	1
		GA	21	51	19	54	2.01 (0.63–6.55)
		AA	14	34	5	15	5.13 (1.23–21.36)
*H. pylori*	Negative	GG	2	11	16	37	1
		GA	22	48	22	51	3.2 (1.00–10.26)
		AA	19	41	5	12	12.16 (2.98–49.64)
	Positive	GG	25	28	21	37	1
		GA	34	39	28	49	1.02 (0.472–-.19)
		AA	29	33	8	14	3.045 (1.15–8.07)

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