Figure 8
From: Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis
Major pathways affected by TFIIS knockdown in MCF7. Network analysis employed Ingenuity® Systems software [31]. The software manufacturer maintains a copyright on the image networks. The Ingenuity networks display in color focus genes that are upregulated (green) and downregulated (red) by other proteins. The affect can be direct (solid lines) or indirect (broken lines). Triangle's represent kinases, diamonds enzymes, ovals Transcription regulators, rectangles G–Protein Coupled receptors and circles, other. The pathway represents MCF7 pathway 1. A list of focus genes for each pathway is provided in Additional file 1.