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Table 1 Characteristics of human colon carcinoma cell lines

From: Clone-specific expression, transcriptional regulation, and action of interleukin-6 in human colon carcinoma cells

  Caco-2/AQ COGA-1A COGA-13
Log phase doubling time (h) 24 15 48
Alkaline phosphatase (mU/μg cellular protein) 60.2 ± 9.1 2.9 ± 0.1 0.7 ± 0.2
Protein    
CK8 +++ +++ +
Vimentin + + +++
Cyclin D1 + ++ +++
p27 +++ ++ +/-
mRNA expression    
CYP24    
basal +/- ++ +++
after 1,25-(OH)2D3 a +++ +++ +++
CYP27B1 +++ +/- +/-
VDR +++ +++ ++
ER-α +/- +/- +/-
ER-β + + +
  1. For details see [5,19,24]. Protein and mRNA expression in confluent cells were classified by visual inspection of Western blots or RT-PCR gels as: nil, -; low, +; medium, ++; high, +++.
  2. aafter treatment with 1,25-(OH)2D3 (cf. [19])