TY - JOUR AU - Zhao, R. AU - Goldman, I. D. PY - 2003 DA - 2003// TI - Resistance to antifolates JO - Oncogene VL - 22 UR - https://doi.org/10.1038/sj.onc.1206946 DO - 10.1038/sj.onc.1206946 ID - Zhao2003 ER - TY - JOUR AU - Gorlick, R. AU - Goker, E. AU - Trippett, T. AU - Waltham, M. AU - Banerjee, D. AU - Bertino, J. R. PY - 1996 DA - 1996// TI - Intrinsic and acquired resistance to methotrexate in acute leukemia JO - N Engl J Med VL - 335 UR - https://doi.org/10.1056/NEJM199610033351408 DO - 10.1056/NEJM199610033351408 ID - Gorlick1996 ER - TY - JOUR AU - Banerjee, D. AU - Mayer-Kuckuk, P. AU - Capiaux, G. AU - Budak-Alpdogan, T. AU - Gorlick, R. AU - Bertino, J. R. PY - 2002 DA - 2002// TI - Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase JO - Biochim Biophys Acta VL - 1587 UR - https://doi.org/10.1016/S0925-4439(02)00079-0 DO - 10.1016/S0925-4439(02)00079-0 ID - Banerjee2002 ER - TY - JOUR AU - Matherly, L. H. AU - Goldman, D. I. PY - 2003 DA - 2003// TI - Membrane transport of folates JO - Vitam Horm VL - 66 UR - https://doi.org/10.1016/S0083-6729(03)01012-4 DO - 10.1016/S0083-6729(03)01012-4 ID - Matherly2003 ER - TY - JOUR AU - Wong, S. C. AU - Proefke, S. A. AU - Bhushan, A. AU - Matherly, L. H. PY - 1995 DA - 1995// TI - Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells JO - J Biol Chem VL - 270 UR - https://doi.org/10.1074/jbc.270.29.17468 DO - 10.1074/jbc.270.29.17468 ID - Wong1995 ER - TY - JOUR AU - Williams, F. M. AU - Flintoff, W. F. PY - 1995 DA - 1995// TI - Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake JO - J Biol Chem VL - 270 UR - https://doi.org/10.1074/jbc.270.7.2987 DO - 10.1074/jbc.270.7.2987 ID - Williams1995 ER - TY - JOUR AU - Prasad, P. D. AU - Ramamoorthy, S. AU - Leibach, F. H. AU - Ganapathy, V. PY - 1995 DA - 1995// TI - Molecular cloning of the human placental folate transporter JO - Biochem Biophys Res Commun VL - 206 UR - https://doi.org/10.1006/bbrc.1995.1096 DO - 10.1006/bbrc.1995.1096 ID - Prasad1995 ER - TY - JOUR AU - Moscow, J. A. AU - Gong, M. AU - He, R. AU - Sgagias, M. K. AU - Dixon, K. H. AU - Anzick, S. L. AU - Meltzer, P. S. AU - Cowan, K. H. PY - 1995 DA - 1995// TI - Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells JO - Cancer Res VL - 55 ID - Moscow1995 ER - TY - JOUR AU - Zhang, L. AU - Taub, J. W. AU - Williamson, M. AU - Wong, S. C. AU - Hukku, B. AU - Pullen, J. AU - Ravindranath, Y. AU - Matherly, L. H. PY - 1998 DA - 1998// TI - Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy JO - Clin Cancer Res VL - 4 ID - Zhang1998 ER - TY - JOUR AU - Gorlick, R. AU - Goker, E. AU - Trippett, T. AU - Steinherz, P. AU - Elisseyeff, Y. AU - Mazumdar, M. AU - Flintoff, W. F. AU - Bertino, J. R. PY - 1997 DA - 1997// TI - Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression JO - Blood VL - 89 ID - Gorlick1997 ER - TY - JOUR AU - Ma, D. AU - Huang, H. AU - Moscow, J. A. PY - 2000 DA - 2000// TI - Down-regulation of reduced folate carrier gene (RFC1) expression after exposure to methotrexate in ZR-75-1 breast cancer cells JO - Biochem Biophys Res Commun VL - 279 UR - https://doi.org/10.1006/bbrc.2000.4019 DO - 10.1006/bbrc.2000.4019 ID - Ma2000 ER - TY - JOUR AU - Guo, W. AU - Healey, J. H. AU - Meyers, P. A. AU - Ladanyi, M. AU - Huvos, A. G. AU - Bertino, J. R. AU - Gorlick, R. PY - 1999 DA - 1999// TI - Mechanisms of methotrexate resistance in osteosarcoma JO - Clin Cancer Res VL - 5 ID - Guo1999 ER - TY - JOUR AU - Whetstine, J. R. AU - Flatley, R. M. AU - Matherly, L. H. PY - 2002 DA - 2002// TI - The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter JO - Biochem J VL - 367 UR - https://doi.org/10.1042/bj20020512 DO - 10.1042/bj20020512 ID - Whetstine2002 ER - TY - JOUR AU - Matherly, L. H. AU - Hou, Z. AU - Deng, Y. PY - 2007 DA - 2007// TI - Human reduced folate carrier: translation of basic biology to cancer etiology and therapy JO - Cancer Metastasis Rev VL - 26 UR - https://doi.org/10.1007/s10555-007-9046-2 DO - 10.1007/s10555-007-9046-2 ID - Matherly2007 ER - TY - JOUR AU - Zhang, L. AU - Wong, S. C. AU - Matherly, L. H. PY - 1998 DA - 1998// TI - Transcript heterogeneity of the human reduced folate carrier results from the use of multiple promoters and variable splicing of alternative upstream exons JO - Biochem J VL - 332 ( Pt 3) UR - https://doi.org/10.1042/bj3320773 DO - 10.1042/bj3320773 ID - Zhang1998 ER - TY - JOUR AU - Tolner, B. AU - Roy, K. AU - Sirotnak, F. M. PY - 1998 DA - 1998// TI - Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5' end heterogeneity JO - Gene VL - 211 UR - https://doi.org/10.1016/S0378-1119(98)00123-1 DO - 10.1016/S0378-1119(98)00123-1 ID - Tolner1998 ER - TY - JOUR AU - Williams, F. M. AU - Flintoff, W. F. PY - 1998 DA - 1998// TI - Structural organization of the human reduced folate carrier gene: evidence for 5' heterogeneity in lymphoblast mRNA JO - Somat Cell Mol Genet VL - 24 UR - https://doi.org/10.1023/B:SCAM.0000007117.50428.63 DO - 10.1023/B:SCAM.0000007117.50428.63 ID - Williams1998 ER - TY - JOUR AU - Gong, M. AU - Cowan, K. H. AU - Gudas, J. AU - Moscow, J. A. PY - 1999 DA - 1999// TI - Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1) JO - Gene VL - 233 UR - https://doi.org/10.1016/S0378-1119(99)00166-3 DO - 10.1016/S0378-1119(99)00166-3 ID - Gong1999 ER - TY - JOUR AU - Whetstine, J. R. AU - Matherly, L. H. PY - 2001 DA - 2001// TI - The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element. Basis for tissue-specific gene expression JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M008074200 DO - 10.1074/jbc.M008074200 ID - Whetstine2001 ER - TY - JOUR AU - Whetstine, J. R. AU - Witt, T. L. AU - Matherly, L. H. PY - 2002 DA - 2002// TI - The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M208296200 DO - 10.1074/jbc.M208296200 ID - Whetstine2002 ER - TY - JOUR AU - Bird, A. PY - 2002 DA - 2002// TI - DNA methylation patterns and epigenetic memory JO - Genes Dev VL - 16 UR - https://doi.org/10.1101/gad.947102 DO - 10.1101/gad.947102 ID - Bird2002 ER - TY - JOUR AU - Jones, P. A. AU - Baylin, S. B. PY - 2002 DA - 2002// TI - The fundamental role of epigenetic events in cancer JO - Nat Rev Genet VL - 3 ID - Jones2002 ER - TY - JOUR AU - Worm, J. AU - Kirkin, A. F. AU - Dzhandzhugazyan, K. N. AU - Guldberg, P. PY - 2001 DA - 2001// TI - Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M103181200 DO - 10.1074/jbc.M103181200 ID - Worm2001 ER - TY - JOUR AU - Moscow, J. A. AU - Connolly, T. AU - Myers, T. G. AU - Cheng, C. C. AU - Paull, K. AU - Cowan, K. H. PY - 1997 DA - 1997// TI - Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines JO - Int J Cancer VL - 72 UR - https://doi.org/3.0.CO;2-I DO - 3.0.CO;2-I ID - Moscow1997 ER - TY - JOUR AU - Li, W. W. AU - Takahashi, N. AU - Jhanwar, S. AU - Cordon-Cardo, C. AU - Elisseyeff, Y. AU - Jimeno, J. AU - Faircloth, G. AU - Bertino, J. R. PY - 2001 DA - 2001// TI - Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent JO - Clin Cancer Res VL - 7 ID - Li2001 ER - TY - JOUR AU - Dedhar, S. AU - Hartley, D. AU - Goldie, J. H. PY - 1985 DA - 1985// TI - Increased dihydrofolate reductase activity in methotrexate-resistant human promyelocytic-leukaemia (HL-60) cells. Lack of correlation between increased activity and overproduction JO - Biochem J VL - 225 UR - https://doi.org/10.1042/bj2250609 DO - 10.1042/bj2250609 ID - Dedhar1985 ER - TY - JOUR AU - Mini, E. AU - Moroson, B. A. AU - Franco, C. T. AU - Bertino, J. R. PY - 1985 DA - 1985// TI - Cytotoxic effects of folate antagonists against methotrexate-resistant human leukemic lymphoblast CCRF-CEM cell lines JO - Cancer Res VL - 45 ID - Mini1985 ER - TY - JOUR AU - Sowers, R. AU - Toguchida, J. AU - Qin, J. AU - Meyers, P. A. AU - Healey, J. H. AU - Huvos, A. AU - Banerjee, D. AU - Bertino, J. R. AU - Gorlick, R. PY - 2003 DA - 2003// TI - mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma JO - Mol Cancer Ther VL - 2 ID - Sowers2003 ER - TY - JOUR AU - Wong, S. C. AU - Zhang, L. AU - Witt, T. L. AU - Proefke, S. A. AU - Bhushan, A. AU - Matherly, L. H. PY - 1999 DA - 1999// TI - Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier JO - J Biol Chem VL - 274 UR - https://doi.org/10.1074/jbc.274.15.10388 DO - 10.1074/jbc.274.15.10388 ID - Wong1999 ER - TY - JOUR AU - Yang, R. AU - Kolb, E. A. AU - Qin, J. AU - Chou, A. AU - Sowers, R. AU - Hoang, B. AU - Healey, J. H. AU - Huvos, A. G. AU - Meyers, P. A. AU - Gorlick, R. PY - 2007 DA - 2007// TI - The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate JO - Clin Cancer Res VL - 13 UR - https://doi.org/10.1158/1078-0432.CCR-06-1343 DO - 10.1158/1078-0432.CCR-06-1343 ID - Yang2007 ER - TY - JOUR AU - Usadel, H. AU - Brabender, J. AU - Danenberg, K. D. AU - Jeronimo, C. AU - Harden, S. AU - Engles, J. AU - Danenberg, P. V. AU - Yang, S. AU - Sidransky, D. PY - 2002 DA - 2002// TI - Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer JO - Cancer Res VL - 62 ID - Usadel2002 ER - TY - JOUR AU - Ferreri, A. J. AU - Dell'Oro, S. AU - Capello, D. AU - Ponzoni, M. AU - Iuzzolino, P. AU - Rossi, D. AU - Pasini, F. AU - Ambrosetti, A. AU - Orvieto, E. AU - Ferrarese, F. AU - Arrigoni, G. AU - Foppoli, M. AU - Reni, M. AU - Gaidano, G. PY - 2004 DA - 2004// TI - Aberrant methylation in the promoter region of the reduced folate carrier gene is a potential mechanism of resistance to methotrexate in primary central nervous system lymphomas JO - Br J Haematol VL - 126 UR - https://doi.org/10.1111/j.1365-2141.2004.05109.x DO - 10.1111/j.1365-2141.2004.05109.x ID - Ferreri2004 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/8/124/prepub UR - http://www.biomedcentral.com/1471-2407/8/124/prepub ID - ref33 ER -