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Table 3 Correlation of HIF-1α, p53, and VEGF expression with preoperative sVEGF level

From: Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer

  p53 HIF-1α VEGF
  - + P -/S D/V P Under Over P
HIF-1α          
   -/S 58 38 0.617*       
   D/V 12 6        
VEGF          
   Under 33 15 0.169* 40 8 0.827*    
   Over 37 29   56 10     
sVEGF (pg/ml)          
   Median 103 139 0.705 147 77 0.438 153 163 0.146
   (range) (8–1076) (6–642)   (6–1076) (6–761)   (8–1076) (6–761)  
  1. * by χ2 test, by Mann-Whitney U test
  2. HIF-1α: hypoxia-inducible factor 1 alpha, VEGF: vascular endothelial growth factor, sVEGF: preoperative serum vascular endothelial growth factor, -/S: negative/superficial pattern, D/V: deep/diffuse/vascular invasion pattern, Under: under-expressed, Over: over-expressed