Skip to main content

Table 1 Expression of HER2/neu ErbB-2 Breast Cancer Signature genes in MAM-1 Co-cultures and the Bam1a cell line

From: A stable explant culture of HER2/neu invasive carcinoma supported by alpha-Smooth Muscle Actin expressing stromal cells to evaluate therapeutic agents

  

Expression Relative to Universal Mouse RNAa

 

Agilent Accession

Genbank Accession

MAM

Bam1a

Gene Description and Symbol

Genes present in the tumor-specific HER-2/neu-Induced Gene Expression Signature described by Astolfi

A_51_P184886

NM_011920

5.27

19.10

Mus musculus ATP-binding cassette, sub-family G (WHITE), member 2 (Abcg2), mRNA [NM_011920]

A_52_P336142

NM_011920

4.90

17.77

Mus musculus ATP-binding cassette, sub-family G (WHITE), member 2 (Abcg2), mRNA [NM_011920]

A_51_P342567

NM_031185

9.10

6.60

Mus musculus A kinase (PRKA) anchor protein (gravin) 12 (Akap12), mRNA [NM_031185]

A_51_P445166

NM_019959

11.89

17.02

Mus musculus C1q and tumor necrosis factor related protein 1 (C1qtnf1), mRNA [NM_019959]

A_51_P455647

NM_009801

7.56

9.21

Mus musculus carbonic anhydrase 2 (Car2), mRNA [NM_009801]

A_51_P303160

NM_007482

14.32

23.23

Mus musculus arginase 1, liver (Arg1), mRNA [NM_007482]

A_52_P159232

NM_011926

20.60

24.52

Mus musculus CEA-related cell adhesion molecule 1 (Ceacam1), mRNA [NM_011926]

A_51_P183446

NM_001039185

10.69

12.16

Mus musculus CEA-related cell adhesion molecule 1, mRNA (cDNA clone MGC:18556 IMAGE:4218391), complete cds [BC016891]

A_51_P171728

NM_011926

9.77

12.34

Mus musculus CEA-related cell adhesion molecule 1 (Ceacam1), mRNA [NM_011926]

A_52_P240706

NM_007543

23.70

31.29

Mus musculus CEA-related cell adhesion molecule 2 (Ceacam2), mRNA [NM_007543]

A_51_P362066

NM_007695

8.34

3.89

Mus musculus chitinase 3-like 1 (Chi3l1), mRNA [NM_007695]

A_51_P495049

NM_009897

10.34

11.46

Mus musculus creatine kinase, mitochondrial 1, ubiquitous (Ckmt1), mRNA [NM_009897]

A_51_P343309

NM_009908

5.83

10.54

Mus musculus cytidine monophospho-N-acetylneuraminic acid synthetase (Cmas), mRNA [NM_009908]

A_52_P197963

NM_009936

7.33

10.23

Mus musculus procollagen, type IX, alpha 3 (Col9a3), mRNA [NM_009936]

A_52_P507877

NM_007729

41.31

30.23

Mus musculus procollagen, type XI, alpha 1 (Col11a1), mRNA [NM_007729]

A_51_P459477

NM_007729

34.68

28.45

Mus musculus procollagen, type XI, alpha 1 (Col11a1), mRNA [NM_007729]

A_51_P227280

NM_007786

53.04

56.89

Mus musculus casein kappa (Csnk), mRNA [NM_007786]

A_51_P227275

NM_007786

26.87

32.53

Mus musculus casein kappa (Csnk), mRNA [NM_007786]

A_52_P51078

NM_007801

23.49

35.47

Mus musculus cathepsin H (Ctsh), mRNA [NM_007801]

A_51_P275976

NM_010070

 

3.24

Mus musculus docking protein 1 (Dok1), mRNA [NM_010070]

A_52_P366842

NM_010070

2.49

4.94

Mus musculus docking protein 1 (Dok1), mRNA [NM_010070]

A_51_P158037

NM_013505

11.59

12.52

Mus musculus desmocollin 2 (Dsc2), mRNA [NM_013505]

A_52_P157158

NM_013505

42.42

46.62

Mus musculus desmocollin 2 (Dsc2), mRNA [NM_013505]

A_52_P252931

NM_013505

107.26

265.33

Mus musculus desmocollin 2 (Dsc2), mRNA [NM_013505]

A_51_P502614

NM_026268

4.28

6.46

Mus musculus dual specificity phosphatase 6 (Dusp6), mRNA [NM_026268]

A_51_P455866

NM_010125

27.80

29.60

Mus musculus E74-like factor 5 (Elf5), mRNA [NM_010125]

A_51_P307979

NM_007960

 

2.46

Mus musculus ets variant gene 1 (Etv1), mRNA [NM_007960]

A_51_P246166

NM_007969

10.06

10.23

Mus musculus extracellular proteinase inhibitor (Expi), mRNA [NM_007969]

A_52_P329207

NM_007969

13.14

12.84

Mus musculus extracellular proteinase inhibitor (Expi), mRNA [NM_007969]

A_51_P329394

NM_008034

6.64

8.48

Mus musculus folate receptor 1 (adult) (Folr1), mRNA [NM_008034]

A_52_P377791

NM_008557

30.34

40.63

Mus musculus FXYD domain-containing ion transport regulator 3 (Fxyd3), mRNA [NM_008557]

A_51_P282538

NM_008077

28.43

73.47

Mus musculus glutamic acid decarboxylase 1 (Gad1), mRNA [NM_008077]

A_52_P144310

NM_008077

27.33

68.46

Mus musculus glutamic acid decarboxylase 1 (Gad1), mRNA [NM_008077]

A_51_P486810

NM_030677

13.90

14.97

Mus musculus glutathione peroxidase 2 (Gpx2), mRNA [NM_030677]

A_51_P258409

NM_010423

13.98

30.78

Mus musculus hairy/enhancer-of-split related with YRPW motif 1 (Hey1), mRNA [NM_010423]

A_51_P365152

NM_010474

23.53

48.48

Mus musculus heparan sulfate (glucosamine) 3-O-sulfotransferase 1 (Hs3st1), mRNA [NM_010474]

A_52_P281702

NM_010518

2.12

3.08

Mus musculus insulin-like growth factor binding protein 5 (Igfbp5), mRNA [NM_010518]

A_51_P204153

NM_010518

4.25

10.70

Mus musculus insulin-like growth factor binding protein 5 (Igfbp5), mRNA [NM_010518]

A_51_P510156

NM_008491

9.56

10.11

Mus musculus lipocalin 2 (Lcn2), mRNA [NM_008491]

A_52_P153864

NM_010723

2.77

3.75

Mus musculus LIM domain only 4 (Lmo4), mRNA [NM_010723]

A_51_P394190

NM_010723

3.05

4.24

Mus musculus LIM domain only 4 (Lmo4), mRNA [NM_010723]

A_52_P415168

NM_019394

8.35

8.26

Mus musculus melanoma inhibitory activity 1 (Mia1), mRNA [NM_019394]

A_52_P415167

NM_019394

18.65

22.26

Mus musculus melanoma inhibitory activity 1 (Mia1), mRNA [NM_019394]

A_52_P174346

NM_019394

7.84

8.15

Mus musculus melanoma inhibitory activity 1 (Mia1), mRNA [NM_019394]

A_51_P220062

NM_008609

10.60

15.42

Mus musculus matrix metalloproteinase 15 (Mmp15), mRNA [NM_008609]

A_51_P139780

NM_009402

6.81

7.64

Mus musculus peptidoglycan recognition protein 1 (Pglyrp1), mRNA [NM_009402]

A_51_P195958

NM_009344

3.26

6.05

Mus musculus pleckstrin homology-like domain, family A, member 1 (Phlda1), mRNA [NM_009344]

A_52_P418791

NM_011254

15.11

16.38

Mus musculus retinol binding protein 1, cellular (Rbp1), mRNA [NM_011254]

A_51_P423484

NM_011254

8.26

7.45

Mus musculus retinol binding protein 1, cellular (Rbp1), mRNA [NM_011254]

A_52_P197215

NM_028777

2.76

4.29

Mus musculus SEC14-like 1 (S. cerevisiae) (Sec14l1), mRNA [NM_028777]

A_52_P197223

NM_028777

3.32

5.72

Mus musculus SEC14-like 1 (S. cerevisiae) (Sec14l1), mRNA [NM_028777]

A_51_P268094

NM_009255

22.21

38.32

Mus musculus serine (or cysteine) proteinase inhibitor, clade E, member 2 (Serpine2), mRNA [NM_009255]

A_52_P637988

NM_009199

40.88

62.00

Mus musculus solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (Slc1a1), mRNA [NM_009199]

A_51_P110759

NM_009199

20.06

26.16

Mus musculus solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (Slc1a1), mRNA [NM_009199]

A_52_P426605

NM_021301

23.10

30.57

Mus musculus solute carrier family 15 (H+/peptide transporter), member 2 (Slc15a2), mRNA [NM_021301]

A_51_P107362

NM_007706

13.23

14.79

Mus musculus suppressor of cytokine signaling 2 (Socs2), mRNA [NM_007706]

A_51_P346704

XM_128139

10.67

11.19

Mus musculus SRY-box containing gene 10, mRNA (cDNA clone MGC:32314 IMAGE:5027211), complete cds. [BC023356]

A_52_P192625

XM_128139

23.80

36.33

Mus musculus SRY-box containing gene 10, mRNA (cDNA clone MGC:32314 IMAGE:5027211), complete cds. [BC023356]

A_52_P161630

NM_145933

 

4.23

Mus musculus beta galactoside alpha 2,6 sialyltransferase 1 (St6gal1), mRNA [NM_145933]

A_51_P101375

NM_145933

2.35

5.29

Mus musculus beta galactoside alpha 2,6 sialyltransferase 1 (St6gal1), mRNA [NM_145933]

A_51_P183940

NM_016866

2.21

3.02

Mus musculus serine/threonine kinase 39, STE20/SPS1 homolog (yeast) (Stk39), mRNA [NM_016866]

A_52_P447944

NM_008532

5.04

8.96

Mus musculus tumor-associated calcium signal transducer 1 (Tacstd1), mRNA [NM_008532]

A_51_P418820

NM_009335

40.16

37.90

Mus musculus transcription factor AP-2, gamma (Tcfap2c), mRNA [NM_009335]

A_51_P338262

NM_011619

5.37

8.17

Mus musculus troponin T2, cardiac (Tnnt2), mRNA [NM_011619]

A_51_P482503

NM_009413

21.46

34.02

Mus musculus tumor protein D52-like 1 (Tpd52l1), mRNA [NM_009413]

A_51_P506822

NM_011674

42.90

81.82

Mus musculus UDP galactosyltransferase 8A (Ugt8a), mRNA [NM_011674]

A_52_P439263

NM_011674

56.91

70.50

Mus musculus UDP galactosyltransferase 8A (Ugt8a), mRNA [NM_011674]

Genes expressed in common with the mouse orthologs of the human "intrinsic" gene list of published by Sorlie

A_51_P311038

NM_001024139

7.11

9.21

Mus musculus a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15 (Adamts15), mRNA [NM_001024139]

A_51_P366811

NM_007470

45.17

36.20

Mus musculus apolipoprotein D (Apod), mRNA [NM_007470]

A_51_P163015

NM_172309

2.77

14.02

Mus musculus aryl hydrocarbon receptor nuclear translocator-like 2 (Arntl2), mRNA [NM_172309]

A_51_P455647

NM_009801

7.57

9.21

Mus musculus carbonic anhydrase 2 (Car2), mRNA [NM_009801]

A_51_P302823

NM_019686

4.02

11.39

Mus musculus calcium and integrin binding family member 2 (Cib2), mRNA [NM_019686]

A_51_P165185

NM_016887

11.54

15.50

Mus musculus claudin 7 (Cldn7), mRNA [NM_016887]

A_52_P507877

NM_007729

41.32

30.23

Mus musculus procollagen, type XI, alpha 1 (Col11a1), mRNA [NM_007729]

A_51_P459477

NM_007729

34.69

28.45

Mus musculus procollagen, type XI, alpha 1 (Col11a1), mRNA [NM_007729]

A_51_P502614

NM_026268

4.28

6.46

Mus musculus dual specificity phosphatase 6 (Dusp6), mRNA [NM_026268]

A_51_P116940

NM_007940

15.92

5.95

Mus musculus epoxide hydrolase 2, cytoplasmic (Ephx2), mRNA [NM_007940]

A_51_P455932

NM_007974

12.81

33.87

Mus musculus coagulation factor II (thrombin) receptor-like 1 (F2rl1), mRNA [NM_007974]

A_52_P192418

NM_010175

2.63

4.90

Mus musculus Fas (TNFRSF6)-associated via death domain (Fadd), mRNA [NM_010175]

A_51_P382925

NM_010175

2.16

3.61

Mus musculus Fas (TNFRSF6)-associated via death domain (Fadd), mRNA [NM_010175]

A_52_P100252

NM_007988

3.23

3.40

Mus musculus clone:A630082H08 product:fatty acid synthase, full insert sequence. [AK080374]

A_52_P136162

NM_010206

2.27

4.37

Mus musculus fibroblast growth factor receptor 1 (Fgfr1), mRNA [NM_010206]

A_52_P668810

NM_010206

 

3.81

Mus musculus fibroblast growth factor receptor 1 (Fgfr1), mRNA [NM_010206]

A_51_P335000

NM_010211

 

5.05

Mus musculus four and a half LIM domains 1 (Fhl1), mRNA [NM_010211]

A_51_P329394

NM_008034

6.64

8.48

Mus musculus folate receptor 1 (adult) (Folr1), mRNA [NM_008034]

A_52_P217710

NM_008056

 

3.08

Mus musculus frizzled homolog 6 (Drosophila) (Fzd6), mRNA [NM_008056]

A_51_P282538

NM_008077

28.43

73.47

Mus musculus glutamic acid decarboxylase 1 (Gad1), mRNA [NM_008077]

A_52_P144310

NM_008077

27.33

68.46

Mus musculus glutamic acid decarboxylase 1 (Gad1), mRNA [NM_008077]

A_51_P380005

NM_015736

32.95

69.29

Mus musculus UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (Galnt3), mRNA [NM_015736]

A_51_P379997

NM_015736

38.50

82.09

Mus musculus UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (Galnt3), mRNA [NM_015736]

A_51_P462422

NM_008124

 

5.07

Mus musculus gap junction membrane channel protein beta 1 (Gjb1), mRNA [NM_008124]

A_52_P16419

NM_010271

2.43

6.66

Mus musculus glycerol-3-phosphate dehydrogenase 1 (soluble) (Gpd1), mRNA [NM_010271]

A_52_P415996

NM_008184

 

6.29

Mus musculus glutathione S-transferase, mu 6 (Gstm6), mRNA [NM_008184]

A_51_P179664

NM_008185

3.67

6.80

Mus musculus glutathione S-transferase, theta 1 (Gstt1), mRNA [NM_008185]

A_52_P281702

NM_010518

2.12

3.08

Mus musculus insulin-like growth factor binding protein 5 (Igfbp5), mRNA [NM_010518]

A_51_P204153

NM_010518

4.25

10.70

Mus musculus insulin-like growth factor binding protein 5 (Igfbp5), mRNA [NM_010518]

A_52_P401386

NM_010593

3.74

5.28

Mus musculus junction plakoglobin (Jup), mRNA [NM_010593]

A_52_P642488

NM_008430

24.28

26.37

Mus musculus potassium channel, subfamily K, member 1 (Kcnk1), mRNA [NM_008430]

A_51_P307964

NM_010662

3.11

6.39

Mus musculus keratin complex 1, acidic, gene 13 (Krt1-13), mRNA [NM_010662]

A_51_P324814

NM_010664

2.93

3.89

Mus musculus keratin complex 1, acidic, gene 18 (Krt1-18), mRNA [NM_010664]

A_52_P410685

NM_033073

12.42

14.59

Mus musculus keratin complex 2, basic, gene 7 (Krt2-7), mRNA [NM_033073]

A_51_P242400

NM_031170

2.56

3.75

Mus musculus keratin complex 2, basic, gene 8 (Krt2-8), mRNA [NM_031170]

A_51_P174943

NM_008485

6.90

10.66

Mus musculus laminin, gamma 2 (Lamc2), mRNA [NM_008485]

A_51_P220062

NM_008609

10.60

15.42

Mus musculus matrix metalloproteinase 15 (Mmp15), mRNA [NM_008609]

A_51_P514085

NM_013606

3.75

6.35

Mus musculus myxovirus (influenza virus) resistance 2 (Mx2), mRNA [NM_013606]

A_52_P608097

NM_008756

17.70

41.15

Mus musculus occludin (Ocln), mRNA [NM_008756]

A_51_P486150

NM_008756

10.05

12.72

Mus musculus occludin (Ocln), mRNA [NM_008756]

A_52_P458279

NM_011169

15.09

21.23

Mus musculus prolactin receptor (Prlr), mRNA [NM_011169]

A_51_P248345

NM_009334

 

17.92

Mus musculus transcription factor AP-2 beta (Tcfap2b), transcript variant 1, mRNA [NM_009334]

A_51_P418820

NM_009335

40.16

37.90

Mus musculus transcription factor AP-2, gamma (Tcfap2c), mRNA [NM_009335]

A_51_P240614

NM_008536

3.79

5.43

Mus musculus transmembrane 4 superfamily member 1 (Tm4sf1), mRNA [NM_008536]

A_51_P482503

NM_009413

21.46

34.02

Mus musculus tumor protein D52-like 1 (Tpd52l1), mRNA [NM_009413]

A_51_P106059

NM_009423

2.81

3.48

Mus musculus Tnf receptor associated factor 4 (Traf4), mRNA [NM_009423]

A_52_P78403

NM_009423

2.90

5.78

Mus musculus Tnf receptor associated factor 4 (Traf4), mRNA [NM_009423]

Genes expressed in common with the MMTV/neu mammary tumor gene signature described by Landis

A_51_P320852

NM_007657

2.52

7.50

Mus musculus CD9 antigen (Cd9), mRNA [NM_007657]

A_51_P242265

NM_009950

2.45

4.36

Mus musculus CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), mRNA [NM_009950]

A_52_P559779

NM_007883

17.30

22.26

Mus musculus desmoglein 2 (Dsg2), mRNA [NM_007883]

A_51_P249848

NM_007883

11.40

13.77

Mus musculus desmoglein 2 (Dsg2), mRNA [NM_007883]

A_52_P88091

NM_007883

22.00

38.20

Mus musculus desmoglein 2 (Dsg2), mRNA [NM_007883]

A_52_P601757

NM_007883

76.45

101.83

Mus musculus desmoglein 2, mRNA (cDNA clone IMAGE:4036406), partial cds [BC034056]

A_51_P502614

NM_026268

4.28

6.46

Mus musculus dual specificity phosphatase 6 (Dusp6), mRNA [NM_026268]

A_51_P246166

NM_007969

10.06

10.23

Mus musculus extracellular proteinase inhibitor (Expi), mRNA [NM_007969]

A_52_P329207

NM_007969

13.14

12.84

Mus musculus extracellular proteinase inhibitor (Expi), mRNA [NM_007969]

A_51_P329394

NM_008034

6.64

8.48

Mus musculus folate receptor 1 (adult) (Folr1), mRNA [NM_008034]

A_51_P352303

NM_011983

5.94

8.58

Mus musculus homer homolog 2 (Drosophila) (Homer2), mRNA [NM_011983]

A_52_P176573

NM_011983

7.52

12.27

Mus musculus homer homolog 2 (Drosophila) (Homer2), mRNA [NM_011983]

A_51_P510156

NM_008491

9.56

10.11

Mus musculus lipocalin 2 (Lcn2), mRNA [NM_008491]

A_52_P382785

NM_033525

3.71

12.17

Mus musculus nephronectin (Npnt), mRNA [NM_033525]

A_51_P289889

NM_033525

3.57

9.38

Mus musculus nephronectin (Npnt), mRNA [NM_033525]

A_52_P17556

NM_134249

6.84

18.37

Mus musculus T-cell immunoglobulin and mucin domain containing 2 (Timd2), mRNA [NM_134249]

A_51_P500906

NM_134249

12.27

24.24

Mus musculus T-cell immunoglobulin and mucin domain containing 2 (Timd2), mRNA [NM_134249]

A_51_P482503

NM_009413

21.46

34.02

Mus musculus tumor protein D52-like 1 (Tpd52l1), mRNA [NM_009413]

Expression of genes associated with the human HER2/neu chromosome 17q amplicon by Bertucci

A_51_P317176

NM_009971

12.40

13.05

Mus musculus colony stimulating factor 3 (granulocyte) (Csf3), mRNA [NM_009971]

A_51_P216179

NM_010152

4.71

8.69

Mus musculus v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2), transcript variant 2, mRNA [NM_010152]

A_51_P230382

NM_008815

2.63

3.66

Mus musculus ets variant gene 4 (E1A enhancer binding protein, E1AF) (Etv4), mRNA [NM_008815]

A_51_P368823

NM_010346

3.09

4.64

Mus musculus growth factor receptor bound protein 7 (Grb7), mRNA [NM_010346]

A_52_P401386

NM_010593

3.74

5.28

Mus musculus junction plakoglobin (Jup), mRNA [NM_010593]

A_52_P567306

NM_010688

2.95

4.98

Mus musculus LIM and SH3 protein 1 (Lasp1), mRNA [NM_010688]

A_51_P182462

NM_010688

2.46

3.44

Mus musculus LIM and SH3 protein 1 (Lasp1), mRNA [NM_010688]

A_51_P387123

NM_011854

2.77

4.06

Mus musculus 2'-5' oligoadenylate synthetase-like 2 (Oasl2), mRNA [NM_011854]

  1. aAverage fold difference is the ratio (n = 3, p value cutoff > .05) MAM-1 or Bam1a RNA to Universal Mouse RNA. RNA from MAM-1 or Bam1a was labeled in red color (cy5), universal RNA is labeled in green (cy3). Three independent RNA preparations per condition were analyzed on three separate chips and averaged; a confidence cutoff of >0.95 was used for the raw values of red/green before normalization. The fold change (**MAM-1 or Bam1a/**Universal Mouse) = Normalized ratio value(cy5/cy3). The MAM-1 and Bam1a transcriptomes include genes that are differentially increased relative to the Universal mouse RNA by at least 2-fold.
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us