Table 1 Clinico-pathological characteristics of the patients
analyzed | |||
|---|---|---|---|
Patients characteristics | all trial patients B 1/2 (n = 1399) | NHL patients (n = 311) | DLBCL patients (n = 205) |
Age Median; yr (range) 75) | 60 (18–75) | 62 (23–75) | 61 (23–75) |
Sex | |||
male | 789 (56%) | 175 (56%) | 115 (56%) |
female | 610 (44%) | 136 (44%) | 90 (44%) |
International Prognostic Index (IPI) | |||
Low (0,1) | 840 (60%) | 176 (57%) | 118 (58%) |
Low intermediate (2) | 250 (18%) | 62 (20%) | 42 (20%) |
High intermediate (3) | 170 (12%) | 46 (15%) | 31 (15%) |
High (4,5) | 139 (10%) | 27 (9%) | 14 (7%) |
Risk Age | |||
Age ≤ 60 yrs | 710 (51%) | 143 (46%) | 98 (48%) |
Age > 60 yrs | 689 (49%) | 168 (54%) | 107(52%) |
Risk extranodal involvement | |||
≤ 1 ex. involvement | 1123 (80%) | 254 (82%) | 174(85%) |
> 1 ex. involvement | 276 (20%) | 57 (18%) | 31(15%) |
Risk ECOG | |||
ECOG 0,1 | 1236 (88%) | 273 (88%) | 178(87%) |
ECOG 2–4 | 163 (12%) | 38 (12%) | 27(13%) |
Risk Stage | |||
Stage I, II | 832 (59%) | 191 (61%) | 134(65%) |
Stage III-IV | 567 (41%) | 120 (39%) | 71(35%) |
Risk LDH | |||
LDH ≤ ONW | 1083 (77%) | 241 (77%) | 160(78%) |
LDH > ONW | 316 (23%) | 70 (23%) | 45(22%) |
Bulky tumor (7.5 cm or larger) | 467 (33%) | 90 (29%) | 62(30%) |