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Table 5 MDM2 SNP309 genotypes

From: Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene

Group MDM2 SNP309 genotypes Cases (n = 635) Controls
    LUCY-study
(n = 472)
HLC-study
(n = 163)
KORA-study
(n = 1300)
gender men TT 128 (41%) 47 (49%) 350 (43%)
   TG 148 (48%) 42 (44%) 366 (45%)
   GG 33 (11%) 7 (7%) 99 (12%)
   unknown 1 (0%)   3 (0%)
  women TT 71 (44%) 24 (36%) 197 (41%)
   TG 74 (46%) 29 (43%) 232 (48%)
   GG 16 (10%) 14 (21%) 50 (10%)
   unknown 1 (0%)   3 (0%)
age at diagnosis ≤ 40 years TT 30 (44%) 11 (50%) 85 (43%)
   TG 30 (44%) 8 (36%) 91 (46%)
   GG 6 (9%) 3 (14%) 21 (11%)
   unknown 2 (3%)   2 (1%)
  41–45 years TT 58 (39%) 21 (43%) 172 (44%)
   TG 73 (49%) 23 (47%) 185 (47%)
   GG 19 (13%) 5 (10%) 37 (9%)
   unknown    1 (0%)
  46–50 years TT 111 (44%) 39 (42%) 290 (41%)
   TG 119 (47%) 40 (43%) 322 (46%)
   GG 24 (9%) 13 (14%) 91 (13%)
   unknown    3 (0%)
smoking exposure level (SEL) minimally exposed TT 28 (49%) 7 (33%) 297 (42%)
  (0–10 PY) TG 19 (33%) 12 (57%) 332 (47%)
   GG 9 (16%) 2 (10%) 81 (11%)
   unknown 1 (2%)   2 (0%)
  lightly exposed (> 10–20 PY) TT 29 (36%) 7 (54%) 72 (40%)
   TG 42 (52%) 5 (38%) 81 (46%)
   GG 9 (11%) 1 (8%) 24 (13%)
   unknown 1 (1%)   1 (1%)
  moderately exposed (> 20–30 PY) TT 65 (45%) 13 (39%) 81 (44%)
   TG 70 (49%) 15 (45%) 86 (46%)
   GG 9 (6%) 5 (15%) 19 (10%)
   unknown    
  highly exposed TT 76 (41%) 41 (48%) 84 (44%)
  (> 30++ PY) TG 89 (48%) 33 (39%) 87 (45%)
   GG 21 (11%) 11 (13%) 21 (11%)
   unknown    
LC subtypes NSCLC- Adenocarcinoma TT 63 (41%) 35 (50%)  
   TG 75 (49%) 23 (33%)  
   GG 13 (9%) 12 (17%)  
   unknown 1 (1%)   
  other NSCLC TT 68 (43%) 17 (30%)  
   TG 73 (46%) 34 (60%)  
   GG 19 (12%) 6 (11%)  
  SCLC TT 55 (45%) 15 (50%)  
   TG 55 (45%) 12 (40%)  
   GG 13 (11%) 3 (10%)  
  other types TT 13 (27%) 4 (40%)  
   TG 19 (39%) 2 (20%)  
   GG 4 (8%)   
   unknown 13 (27%) 4 (40%)