Table 5 MDM2 SNP309 genotypes
From: Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene
Group | MDM2 SNP309 genotypes | Cases (n = 635) | Controls | ||
|---|---|---|---|---|---|
LUCY-study (n = 472) | HLC-study (n = 163) | KORA-study (n = 1300) | |||
gender | men | TT | 128 (41%) | 47 (49%) | 350 (43%) |
TG | 148 (48%) | 42 (44%) | 366 (45%) | ||
GG | 33 (11%) | 7 (7%) | 99 (12%) | ||
unknown | 1 (0%) | 3 (0%) | |||
women | TT | 71 (44%) | 24 (36%) | 197 (41%) | |
TG | 74 (46%) | 29 (43%) | 232 (48%) | ||
GG | 16 (10%) | 14 (21%) | 50 (10%) | ||
unknown | 1 (0%) | 3 (0%) | |||
age at diagnosis | ≤ 40 years | TT | 30 (44%) | 11 (50%) | 85 (43%) |
TG | 30 (44%) | 8 (36%) | 91 (46%) | ||
GG | 6 (9%) | 3 (14%) | 21 (11%) | ||
unknown | 2 (3%) | 2 (1%) | |||
41–45 years | TT | 58 (39%) | 21 (43%) | 172 (44%) | |
TG | 73 (49%) | 23 (47%) | 185 (47%) | ||
GG | 19 (13%) | 5 (10%) | 37 (9%) | ||
unknown | 1 (0%) | ||||
46–50 years | TT | 111 (44%) | 39 (42%) | 290 (41%) | |
TG | 119 (47%) | 40 (43%) | 322 (46%) | ||
GG | 24 (9%) | 13 (14%) | 91 (13%) | ||
unknown | 3 (0%) | ||||
smoking exposure level (SEL) | minimally exposed | TT | 28 (49%) | 7 (33%) | 297 (42%) |
(0–10 PY) | TG | 19 (33%) | 12 (57%) | 332 (47%) | |
GG | 9 (16%) | 2 (10%) | 81 (11%) | ||
unknown | 1 (2%) | 2 (0%) | |||
lightly exposed (> 10–20 PY) | TT | 29 (36%) | 7 (54%) | 72 (40%) | |
TG | 42 (52%) | 5 (38%) | 81 (46%) | ||
GG | 9 (11%) | 1 (8%) | 24 (13%) | ||
unknown | 1 (1%) | 1 (1%) | |||
moderately exposed (> 20–30 PY) | TT | 65 (45%) | 13 (39%) | 81 (44%) | |
TG | 70 (49%) | 15 (45%) | 86 (46%) | ||
GG | 9 (6%) | 5 (15%) | 19 (10%) | ||
unknown | |||||
highly exposed | TT | 76 (41%) | 41 (48%) | 84 (44%) | |
(> 30++ PY) | TG | 89 (48%) | 33 (39%) | 87 (45%) | |
GG | 21 (11%) | 11 (13%) | 21 (11%) | ||
unknown | |||||
LC subtypes | NSCLC- Adenocarcinoma | TT | 63 (41%) | 35 (50%) | |
TG | 75 (49%) | 23 (33%) | |||
GG | 13 (9%) | 12 (17%) | |||
unknown | 1 (1%) | ||||
other NSCLC | TT | 68 (43%) | 17 (30%) | ||
TG | 73 (46%) | 34 (60%) | |||
GG | 19 (12%) | 6 (11%) | |||
SCLC | TT | 55 (45%) | 15 (50%) | ||
TG | 55 (45%) | 12 (40%) | |||
GG | 13 (11%) | 3 (10%) | |||
other types | TT | 13 (27%) | 4 (40%) | ||
TG | 19 (39%) | 2 (20%) | |||
GG | 4 (8%) | ||||
unknown | 13 (27%) | 4 (40%) | |||