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Table 4 Association of MDM2 SNP309 with lung cancer within NSCLC cases

From: Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene

genotype

OR

95% CI

p-value

all: NSCLC cases (n = 434) vs. controls (n = 1295)

TG vs. GG

1.1§

0.7–1.6

0.828

TT vs. GG

1.0§

0.7–1.5

0.841

men: NSCLC cases (n = 280) vs. controls (n = 815)

TG vs. GG

1.2§§

0.7–2.9

0.422

TT vs. GG

1.2§§

0.7–2.9

0.515

women: NSCLC cases (n = 154) vs. controls (n = 479)

TG vs. GG

0.8§§

0.4–1.6

0.471

TT vs. GG

0.7§§

0.4–4.0

0.323

gender difference in genotypic ORs

0.237

  1. § conditional to age/gender-strata (6 groups) and adjusted for smoking exposure§§ conditional to age-strata (3 groups) and adjusted for smoking exposure and gender