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Table 3 Association of MDM2 SNP309 with lung cancer

From: Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene

gender

Genotype

OR

95% CI

p-value

men*

TG vs. GG

1.1

0.7 – 2.0

0.630

men*

TT vs. GG

1.2

0.7 – 2.2

0.504

women*

TG vs. GG

0.9

0.5 – 1.6

0.723

women*

TT vs. GG

0.8

0.5 – 1.3

0.565

histology

    

NSCLC-Adenocarcinoma**

TG vs. GG

1.0

0.6 – 1.7

0.991

NSCLC-Adenocarcinoma**

TT vs. GG

1.0

0.6 – 1.8

0.890

other NSCLC**

TG vs. GG

1.0

0.6 – 1.8

0.873

other NSCLC**

TT vs. GG

0.9

0.5 – 1.6

0.751

SCLC**

TG vs. GG

1.0

0.5 – 1.9

0.980

SCLC**

TT vs. GG

1.2

0.6 – 2.1

0.637

smoking exposure (packyears)

    

lightly exposed (11–20 PY)***

TT vs. GG

1.0

0.6 – 1.8

0.928

lightly exposed (11–20 PY)***

TG vs. GG

1.0

0.5 – 1.7

0.857

moderately exposed (21–30 PY)***

TT vs. GG

1.0

0.6 – 1.7

0.960

moderately exposed (21–30 PY)***

TG vs. GG

0.9

0.6 – 1.6

0.822

highly exposed (31++ PY)***

TT vs. GG

0.9

0.5 – 1.4

0.595

highly exposed (31++ PY)***

TG vs. GG

0.8

0.5 – 1.3

0.369

  1. *conditional to age-strata (3 groups: ≤ 40 years, 41–45 years, 46–50 years), adjusted for smoking exposure; **conditional to age/gender-strata (6 groups) and adjusted for smoking exposure; ***conditional to age/gender-strata (6 groups)