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Table 3 Association of MDM2 SNP309 with lung cancer

From: Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene

gender Genotype OR 95% CI p-value
men* TG vs. GG 1.1 0.7 – 2.0 0.630
men* TT vs. GG 1.2 0.7 – 2.2 0.504
women* TG vs. GG 0.9 0.5 – 1.6 0.723
women* TT vs. GG 0.8 0.5 – 1.3 0.565
histology     
NSCLC-Adenocarcinoma** TG vs. GG 1.0 0.6 – 1.7 0.991
NSCLC-Adenocarcinoma** TT vs. GG 1.0 0.6 – 1.8 0.890
other NSCLC** TG vs. GG 1.0 0.6 – 1.8 0.873
other NSCLC** TT vs. GG 0.9 0.5 – 1.6 0.751
SCLC** TG vs. GG 1.0 0.5 – 1.9 0.980
SCLC** TT vs. GG 1.2 0.6 – 2.1 0.637
smoking exposure (packyears)     
lightly exposed (11–20 PY)*** TT vs. GG 1.0 0.6 – 1.8 0.928
lightly exposed (11–20 PY)*** TG vs. GG 1.0 0.5 – 1.7 0.857
moderately exposed (21–30 PY)*** TT vs. GG 1.0 0.6 – 1.7 0.960
moderately exposed (21–30 PY)*** TG vs. GG 0.9 0.6 – 1.6 0.822
highly exposed (31++ PY)*** TT vs. GG 0.9 0.5 – 1.4 0.595
highly exposed (31++ PY)*** TG vs. GG 0.8 0.5 – 1.3 0.369
  1. *conditional to age-strata (3 groups: ≤ 40 years, 41–45 years, 46–50 years), adjusted for smoking exposure; **conditional to age/gender-strata (6 groups) and adjusted for smoking exposure; ***conditional to age/gender-strata (6 groups)