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Table 2 Association of MDM2 SNP309 with lung cancer within both case-populations

From: Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene

genotype OR 95% CI p-value
LUCY cases (n = 470) vs. KORA controls (n = 815)
TG vs. GG 1.1§ 0.7–1.6 0.794
TT vs. GG 1.0§ 0.7–1.6 0.841
men: LUCY cases (n = 309) vs. KORA controls (n = 815)
TG vs. GG 1.1§§ 0.7–1.8 0.706
TT vs. GG 1.1§§ 0.7–1.8 0.751
women: LUCY cases (n = 161) vs. KORA controls (n = 815)
TG vs. GG 1.0§§ 0.5–2.1 0.937
TT vs. GG 1.0§§ 0.5–2.1 0.966
gender difference in genotypic ORs 0.778
HLC cases (n = 163) vs. KORA controls (n = 479)
TG vs. GG 0.9§ 0.5–1.7 0.761
TT vs. GG 1.0§ 0.5–1.7 0.906
men: HLC cases (n = 96) vs. KORA controls (n = 479)
TG vs. GG 1.2§§ 0.5–3.0 0.648
TT vs. GG 1.6§§ 0.7–3.7 0.314
women: HLC cases (n = 67) vs. KORA controls (n = 479)
TG vs. GG 0.7§§ 0.3–1.6 0.372
TT vs. GG 0.5§§ 0.2–1.3 0.159
gender difference in genotypic ORs 0.083
HLC cases vs. LUCY cases (distribution of TT/TG/GG)
all    $0.773
men    $0.383
women    $0.100
  1. § conditional to age/gender-strata (6 groups) and adjusted for smoking exposure§§ conditional to age-strata (3 groups) and adjusted for smoking exposure and gender$. Fishers Exact Test