Table 2 Association of MDM2 SNP309 with lung cancer within both case-populations
From: Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene
genotype | OR | 95% CI | p-value |
|---|---|---|---|
LUCY cases (n = 470) vs. KORA controls (n = 815) | |||
TG vs. GG | 1.1§ | 0.7–1.6 | 0.794 |
TT vs. GG | 1.0§ | 0.7–1.6 | 0.841 |
men: LUCY cases (n = 309) vs. KORA controls (n = 815) | |||
TG vs. GG | 1.1§§ | 0.7–1.8 | 0.706 |
TT vs. GG | 1.1§§ | 0.7–1.8 | 0.751 |
women: LUCY cases (n = 161) vs. KORA controls (n = 815) | |||
TG vs. GG | 1.0§§ | 0.5–2.1 | 0.937 |
TT vs. GG | 1.0§§ | 0.5–2.1 | 0.966 |
gender difference in genotypic ORs | 0.778 | ||
HLC cases (n = 163) vs. KORA controls (n = 479) | |||
TG vs. GG | 0.9§ | 0.5–1.7 | 0.761 |
TT vs. GG | 1.0§ | 0.5–1.7 | 0.906 |
men: HLC cases (n = 96) vs. KORA controls (n = 479) | |||
TG vs. GG | 1.2§§ | 0.5–3.0 | 0.648 |
TT vs. GG | 1.6§§ | 0.7–3.7 | 0.314 |
women: HLC cases (n = 67) vs. KORA controls (n = 479) | |||
TG vs. GG | 0.7§§ | 0.3–1.6 | 0.372 |
TT vs. GG | 0.5§§ | 0.2–1.3 | 0.159 |
gender difference in genotypic ORs | 0.083 | ||
HLC cases vs. LUCY cases (distribution of TT/TG/GG) | |||
all | $0.773 | ||
men | $0.383 | ||
women | $0.100 | ||