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Table 1 Characteristics of lung cancer cases and healthy controls

From: Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene

Category Group Cases (n = 635) Controls
   LUCY-study
(n = 472)
HLC-study
(n = 163)
KORA-study
(n = 1300)
gender men 66% (310) 59% (96) 63% (819)
  women 34% (162) 41% (67) 37% (481)
age at diagnosis (mean ± SD) men 45.4 ± 4.1 45.4 ± 3.7 45.2 ± 4.3
  women 44.5 ± 4.6 45.1 ± 4.6 44.7 ± 4.7
age at diagnosis (men) ≤ 40 years 13% (40) 11% (11) 14% (116)
  41–45 years 32% (99) 33% (32) 31% (251)
  46–50 years 55% (171) 55% (53) 55% (451)
age at diagnosis (women) ≤ 40 years 17% (28) 16% (11) 17% (83)
  41–45 years 31% (51) 25% (17) 30% (144)
  46–50 years 51% (83) 58% (39) 53% (255)
LC subtypes (men) NSCLC-Adenocarcinoma 26% (81) 35% (34)  
  other NSCLC 40% (125) 43% (41)  
  SCLC 26% (81) 20% (19)  
  other types 7% (22) 2% (2)  
LC subtypes (women) NSCLC-Adenocarcinoma 44% (71) 54% (36)  
  other NSCLC 22% (36) 24% (16)  
  SCLC 25% (41) 16% (11)  
  other types 9% (14) 6% (4)  
smoking exposure (packyears) minimally exposed (0–10) 12% (57) 13% (21) 54% (712)
  lightly exposed (11–20) 17% (81) 8% (13) 14% (178)
  moderately exposed (21–30) 31% (144) 20% (33) 15% (188)
  highly exposed (31++) 39% (186) 52% (85) 15% (192)
  unknown 0.9% (4) 7% (11) 2% (30)
MDM2 SNP309 genotypes* TT 42% (199) 44% (71) 42% (547)
  TG 47% (222) 44% (71) 46% (598)
  GG 10% (49) 13% (21) 12% (149)
  unknown 0.3% (2) -- 0.5% (6)
mean age at diagnosis (95% CI) TT 45.1 (44.5–45.7) 44.8 (43.7–45.8)  
  TG 45.3 (44.7–45.8) 45.6 (44.7–46.5)  
  GG 44.6 (43.3–45.9) 45.9 (44.2–47.6)  
  1. LUCY-study: Lung Cancer in the Young study; HLC-Study: Heidelberg lung cancer study; Other NSCLC = other non small cell lung cancers (NSCLC excluding adenocarcinoma), SCLC = small cell lung cancer, other types = other kinds of lung cancer