Table 1 Characteristics of lung cancer cases and healthy controls
From: Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene
Category | Group | Cases (n = 635) | Controls | |
|---|---|---|---|---|
LUCY-study (n = 472) | HLC-study (n = 163) | KORA-study (n = 1300) | ||
gender | men | 66% (310) | 59% (96) | 63% (819) |
women | 34% (162) | 41% (67) | 37% (481) | |
age at diagnosis (mean ± SD) | men | 45.4 ± 4.1 | 45.4 ± 3.7 | 45.2 ± 4.3 |
women | 44.5 ± 4.6 | 45.1 ± 4.6 | 44.7 ± 4.7 | |
age at diagnosis (men) | ≤ 40 years | 13% (40) | 11% (11) | 14% (116) |
41–45 years | 32% (99) | 33% (32) | 31% (251) | |
46–50 years | 55% (171) | 55% (53) | 55% (451) | |
age at diagnosis (women) | ≤ 40 years | 17% (28) | 16% (11) | 17% (83) |
41–45 years | 31% (51) | 25% (17) | 30% (144) | |
46–50 years | 51% (83) | 58% (39) | 53% (255) | |
LC subtypes (men) | NSCLC-Adenocarcinoma | 26% (81) | 35% (34) | |
other NSCLC | 40% (125) | 43% (41) | ||
SCLC | 26% (81) | 20% (19) | ||
other types | 7% (22) | 2% (2) | ||
LC subtypes (women) | NSCLC-Adenocarcinoma | 44% (71) | 54% (36) | |
other NSCLC | 22% (36) | 24% (16) | ||
SCLC | 25% (41) | 16% (11) | ||
other types | 9% (14) | 6% (4) | ||
smoking exposure (packyears) | minimally exposed (0–10) | 12% (57) | 13% (21) | 54% (712) |
lightly exposed (11–20) | 17% (81) | 8% (13) | 14% (178) | |
moderately exposed (21–30) | 31% (144) | 20% (33) | 15% (188) | |
highly exposed (31++) | 39% (186) | 52% (85) | 15% (192) | |
unknown | 0.9% (4) | 7% (11) | 2% (30) | |
MDM2 SNP309 genotypes* | TT | 42% (199) | 44% (71) | 42% (547) |
TG | 47% (222) | 44% (71) | 46% (598) | |
GG | 10% (49) | 13% (21) | 12% (149) | |
unknown | 0.3% (2) | -- | 0.5% (6) | |
mean age at diagnosis (95% CI) | TT | 45.1 (44.5–45.7) | 44.8 (43.7–45.8) | |
TG | 45.3 (44.7–45.8) | 45.6 (44.7–46.5) | ||
GG | 44.6 (43.3–45.9) | 45.9 (44.2–47.6) | ||