From: Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk
NOD2 WT/WT | NOD2 WT/insC + insC/insC | ||||||
---|---|---|---|---|---|---|---|
Age groups | Gene | Controls | CRC | OR (95% CI) | Controls | CRC | OR (95% CI) |
≤ 50 | TNFα T/T | 65 | 61 | 1.00 | 6 | 2 | 0.34 (0.07–1.80) |
TNFα T/C | 23 | 29 | 1.36 (0.71–2.62) | 1 | 3 | 3.18 (0.32–31.47) | |
TNFα C/C | 3 | 4 | 1.44 (0.31–6.70) | 1 | 0 | 0.00 | |
p = 0.22 | |||||||
>50 | TNFα T/T | 319 | 329 | 1.00 | 21 | 39 | 1.80 (1.04–3.14) |
TNFα T/C | 127 | 113 | 0.86 (0.64–1.16) | 19 | 12.6 | 0.82 (0.41–1.62) | |
TNFα C/C | 21 | 8 | 0.37 (0.16–0.84) | 1 | 3 | 2.95 (0.30–28.58) | |
p = 0.12 | |||||||
>60 | TNFα T/T | 236 | 245 | 1.00 | 16 | 31 | 1.87 (1.00–3.52) |
TNFα T/C | 98 | 85 | 0.83 (0.59–1.17) | 17 | 14 | 0.80 (0.38–1.65) | |
TNFα C/C | 16 | 5 | 0.29 (0.11–0.82) | 0 | 3 | --- | |
p = 0.02 | |||||||
>70 | TNFα T/T | 111 | 119 | 1.00 | 9 | 20 | 2.08 (0.91–4.76) |
TNFα T/C | 51 | 37 | 0.67 (0.41–1.11) | 9 | 6 | 0.63 (0.22–1.83) | |
TNFα C/C | 6 | 3 | 0.46 (0.11–1.89) | 0 | 1 | --- | |
p = 0.24 |