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Table 3 Frequency of the combined genotypes (TNFα-1031T/C & NOD2 3020insC) and changes in the OR with increasing age of diagnosis in consecutively collected colorectal cancer patients.

From: Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk

   NOD2 WT/WT NOD2 WT/insC + insC/insC
Age groups Gene Controls CRC OR (95% CI) Controls CRC OR (95% CI)
≤ 50 TNFα T/T 65 61 1.00 6 2 0.34 (0.07–1.80)
  TNFα T/C 23 29 1.36 (0.71–2.62) 1 3 3.18 (0.32–31.47)
  TNFα C/C 3 4 1.44 (0.31–6.70) 1 0 0.00
p = 0.22        
>50 TNFα T/T 319 329 1.00 21 39 1.80 (1.04–3.14)
  TNFα T/C 127 113 0.86 (0.64–1.16) 19 12.6 0.82 (0.41–1.62)
  TNFα C/C 21 8 0.37 (0.16–0.84) 1 3 2.95 (0.30–28.58)
p = 0.12        
>60 TNFα T/T 236 245 1.00 16 31 1.87 (1.00–3.52)
  TNFα T/C 98 85 0.83 (0.59–1.17) 17 14 0.80 (0.38–1.65)
  TNFα C/C 16 5 0.29 (0.11–0.82) 0 3 ---
p = 0.02        
>70 TNFα T/T 111 119 1.00 9 20 2.08 (0.91–4.76)
  TNFα T/C 51 37 0.67 (0.41–1.11) 9 6 0.63 (0.22–1.83)
  TNFα C/C 6 3 0.46 (0.11–1.89) 0 1 ---
p = 0.24