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Table 1 Screening of polymorphisms tested for association with CRC between cases and sex, age and geographically matched controls.

From: Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk

Gene/Change Age groups Genotype Matched controls n = 607 CRC cases n = 607 OR (95% CI) p-value
NOD2/3020insC consecutive WT/WT 558 (91.9%) 544 (89.6%) 1.00 0.065
   WT/insC 49 (8.1%) 60 (9.9%) 1.26 (0.85–1.87)  
   insC/insC 0 (0%) 3 (0.5%) NA  
  ≤ 50 WT/WT 91 (91.9%) 94 (95%) 1.00 0.38
   WT/insC 8 (8.1%) 5 (5%) 0.60 (0.19–1.92)  
  >50 WT/WT 467 (91.9%) 450 (88.6%) 1.00 0.038
   WT/insC 41 (8.1%) 55 (10.8%) 1.39 (0.91–2.14)  
   insC/insC 0 (0%) 3 (0.6%) NA  
  >60 WT/WT 350 (91.4%) 335 (87.5%) 1.00 0.042
   WT/insC 33 (8.6%) 45 (11.8%) 1.43 (0.89–2.29)  
   insC/insC 0 (0%) 3 (0.8%) NA  
  >70 WT/WT 168 (90.3%) 159 (85.5%) 1.00 0.15
   WT/insC 18 (9.7%) 27 (14.5%) 1.59 (0.84–3.01)  
TNFα/-1031 T/C consecutive T/T 411 (67.7%) 431 (71%) 1.00 0.14
   T/C 170 (28%) 161 (26.5%) 0.89 (0.69–1.15)  
   C/C 26 (4.3%) 15 (2.5%) 0.54 (0.28–1.04)  
  ≤50 T/T 71 (71.7%) 63 (63.6%) 1.00 0.42
   T/C 24 (24.2%) 32 (32.3%) 1.53 (0.81–2.90)  
   C/C 4 (4%) 4 (4%) 1.19 (0.28–5.01)  
  >50 T/T 340 (66.9%) 368 (72.4%) 1.00 0.04
   T/C 146 (28.7%) 129 (25.4%) 0.80 (0.61–1.06)  
   C/C 22 (4.3%) 11 (2.2%) 0.45 (0.22–0.95)  
  >60 T/T 252 (65.8%) 276 (72.1%) 1.00 0.059
   T/C 115 (30%) 99 (25.9%) 0.76 (0.55–1.05)  
   C/C 16 (4.2%) 8 (2.1%) 0.44 (0.18–1.05)  
  >70 T/T 120 (64.5%) 139 (74.7%) 1.00 0.084
   T/C 60 (32.3%) 43 (23.1%) 0.61 (0.38–0.96)  
   C/C 6 (3.2%) 4 (2.1%) 0.57 (0.15–2.08)