Table 1 Screening of polymorphisms tested for association with CRC between cases and sex, age and geographically matched controls.
From: Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk
| Gene/Change | Age groups | Genotype | Matched controls n = 607 | CRC cases n = 607 | OR (95% CI) | p-value |
|---|---|---|---|---|---|---|
| NOD2/3020insC | consecutive | WT/WT | 558 (91.9%) | 544 (89.6%) | 1.00 | 0.065 |
| WT/insC | 49 (8.1%) | 60 (9.9%) | 1.26 (0.85–1.87) | |||
| insC/insC | 0 (0%) | 3 (0.5%) | NA | |||
| ≤ 50 | WT/WT | 91 (91.9%) | 94 (95%) | 1.00 | 0.38 | |
| WT/insC | 8 (8.1%) | 5 (5%) | 0.60 (0.19–1.92) | |||
| >50 | WT/WT | 467 (91.9%) | 450 (88.6%) | 1.00 | 0.038 | |
| WT/insC | 41 (8.1%) | 55 (10.8%) | 1.39 (0.91–2.14) | |||
| insC/insC | 0 (0%) | 3 (0.6%) | NA | |||
| >60 | WT/WT | 350 (91.4%) | 335 (87.5%) | 1.00 | 0.042 | |
| WT/insC | 33 (8.6%) | 45 (11.8%) | 1.43 (0.89–2.29) | |||
| insC/insC | 0 (0%) | 3 (0.8%) | NA | |||
| >70 | WT/WT | 168 (90.3%) | 159 (85.5%) | 1.00 | 0.15 | |
| WT/insC | 18 (9.7%) | 27 (14.5%) | 1.59 (0.84–3.01) | |||
| TNFα/-1031 T/C | consecutive | T/T | 411 (67.7%) | 431 (71%) | 1.00 | 0.14 |
| T/C | 170 (28%) | 161 (26.5%) | 0.89 (0.69–1.15) | |||
| C/C | 26 (4.3%) | 15 (2.5%) | 0.54 (0.28–1.04) | |||
| ≤50 | T/T | 71 (71.7%) | 63 (63.6%) | 1.00 | 0.42 | |
| T/C | 24 (24.2%) | 32 (32.3%) | 1.53 (0.81–2.90) | |||
| C/C | 4 (4%) | 4 (4%) | 1.19 (0.28–5.01) | |||
| >50 | T/T | 340 (66.9%) | 368 (72.4%) | 1.00 | 0.04 | |
| T/C | 146 (28.7%) | 129 (25.4%) | 0.80 (0.61–1.06) | |||
| C/C | 22 (4.3%) | 11 (2.2%) | 0.45 (0.22–0.95) | |||
| >60 | T/T | 252 (65.8%) | 276 (72.1%) | 1.00 | 0.059 | |
| T/C | 115 (30%) | 99 (25.9%) | 0.76 (0.55–1.05) | |||
| C/C | 16 (4.2%) | 8 (2.1%) | 0.44 (0.18–1.05) | |||
| >70 | T/T | 120 (64.5%) | 139 (74.7%) | 1.00 | 0.084 | |
| T/C | 60 (32.3%) | 43 (23.1%) | 0.61 (0.38–0.96) | |||
| C/C | 6 (3.2%) | 4 (2.1%) | 0.57 (0.15–2.08) |