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Table 2 Patterns of failure and severe late toxicity

From: Prospective single-arm study of 72 Gy hyperfractionated radiation therapy and combination chemotherapy for anaplastic astrocytomas

Total failure 14/44 (32%)
Failure inside field 7/14 (50%)
Failure outside field 10/14 (71%) (CSF dissemination: 9, contralateral brain: 1)
Severe late toxicity  
Brain necrosis 1 (2%)