Explorative data analysis of MCL reveals gene expression networks implicated in survival and prognosis supported by explorative CGH analysis

Table 2 Most significant genes separating good (s) and bad (b) prognosis

Acc	Gene	Fold change	p-value	EnsemblID
7019	CDC2	1.3737029	1.8651454E-13	ENSG00000170312
6632	NP_057427.3	0.94384	3.4574367E-13	ENSG00000117724
3399	UHRF1	1.1446086	1.5513529E-12	ENSG00000034063
5112	NP_060880.2	1.0916529	1.5513529E-12	ENSG00000123485
6994	AURKB	1.4594886	1.5513529E-12	ENSG00000178999
6388	MKI67	1.5062114	1.7304206E-12	ENSG00000148773
6721	Q9Y645_HUMAN	1.2185314	3.2408542E-12	ENSG00000140451
7024	BUB1	1.2488679	3.2408542E-12	ENSG00000169679
6392	NP_057427.3	1.3208085	3.2902188E-12	ENSG00000117724
5726	MKI67	1.4871315	3.6012686E-12	ENSG00000148773
6029	NP_057427.3	1.2980943	5.249176E-12	ENSG00000117724
7423	BIRC5	1.3726515	6.49239E-12	ENSG00000089685
4985	ASPM	1.3310171	7.281489E-12	ENSG00000066279
5754	KIF23	1.2461857	1.6424877E-11	ENSG00000137807
5271	ASPM	1.3205649	2.2259293E-11	ENSG00000066279
6104	KIF23	1.1683029	2.4981522E-11	ENSG00000137807

The most significant differentially expressed genes regarding good ("s") or bad ("b") prognosis determined with a moderate t-test. P-values were corrected for multiple testing [13]. The gene "cell division cycle 2" (CDC2), which is important for the transition G1 to S and G2 to M shows the biggest difference in gene expression between the two groups. This indicates that these cell cycle transitions are part of the difference between the two groups.

ISSN: 1471-2407